Clinical pharmacology of tobramycin in infants.
作者信息
Bratlid D, Fuglesang J E
出版信息
Scand J Infect Dis. 1979;11(1):73-6. doi: 10.3109/inf.1979.11.issue-1.12.
PMID:419372
Abstract
Tobramycin was used in the treatment of severe infections in infants, mostly newborns and prematures. Serum half-life of the drug was 3.5 h in infants older than one week and above 2,500 g, and 8.0 h in infants below one week and less than 2,500 g. Apparent volume of distribution was similar in both groups, 0.24 l/kg. Intravenous infusions of the drug gave considerably higher plasma levels than intramuscular infections. Particularly in the newborn and premature group intramuscular injections gave fairly unpredictable plasma concentrations.
摘要
相似文献
1
Clinical pharmacology of tobramycin in infants.
Scand J Infect Dis. 1979;11(1):73-6. doi: 10.3109/inf.1979.11.issue-1.12.
2
Tobramycin kinetics in newborn infants.
J Pediatr. 1983 Jul;103(1):136-8. doi: 10.1016/s0022-3476(83)80800-2.
3
Tobramycin sulfate elimination in premature infants.
J Pediatr. 1983 Jul;103(1):131-5. doi: 10.1016/s0022-3476(83)80799-9.
4
[Value of tobramycin in pediatrics. Apropos of 40 cases].
Nouv Presse Med. 1974 Apr 27;3(0):72-4.
5
Pharmacologic evaluation of gentamicin in newborn infants.庆大霉素在新生儿中的药理学评估。
J Infect Dis. 1971 Dec;124 Suppl:S214- 23. doi: 10.1093/infdis/124.supplement_1.s214.
6
Tobramycin in patients with various infections: a clinical evaluation.
Scand J Infect Dis. 1978;10(3):229-34. doi: 10.3109/inf.1978.10.issue-3.13.
7
Tobramycin dosage in infants and children.
Lancet. 1978 Dec 9;2(8102):1264. doi: 10.1016/s0140-6736(78)92145-1.
8
[Fundamental and clinical studies on tobramycin by intravenous drip infusion (author's transl)].
Jpn J Antibiot. 1981 Nov;34(11):1436-46.
9
Evaluation of three antibiotic programs in newborn infants.新生儿三种抗生素治疗方案的评估。
Can Med Assoc J. 1978 Mar 18;118(6):659-62.
10
[Clinical usefulness of cefmetazole in newborn and immature infants (author's transl)].
Jpn J Antibiot. 1981 Jun;34(6):893-902.
Zotero 插件