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The mechanism of the antihypertensive action of -methyldopa in hypertensive rats.

作者信息

Day M D, Roach A G, Whiting R L

出版信息

Eur J Pharmacol. 1973 Mar;21(3):271-80. doi: 10.1016/0014-2999(73)90126-x.

DOI:10.1016/0014-2999(73)90126-x
PMID:4196583
Abstract
摘要

相似文献

1
The mechanism of the antihypertensive action of -methyldopa in hypertensive rats.
Eur J Pharmacol. 1973 Mar;21(3):271-80. doi: 10.1016/0014-2999(73)90126-x.
2
[Relationship between the antihypertensive activity of methyldopa and the appearance of its metabolites in the heart and brain of the hypertensive rat].
Arch Int Pharmacodyn Ther. 1974 Feb;207(2):348-60.
3
The mode of action of -methyldopa.α-甲基多巴的作用方式。
Br J Pharmacol. 1972 May;45(1):168P-169P.
4
Central inhibitory effect of alpha-methyldopa on blood pressure, heart rate and body temperature of renal hypertensive rats.α-甲基多巴对肾性高血压大鼠血压、心率及体温的中枢抑制作用。
Eur J Pharmacol. 1975 Apr;31(2):243-9. doi: 10.1016/0014-2999(75)90046-1.
5
Influence of the decarboxylase inhibitor benserazide on the antihypertensive effect and metabolism of alpha-methyldopa in patients with essential hypertension.脱羧酶抑制剂苄丝肼对原发性高血压患者中α-甲基多巴的降压作用及代谢的影响。
Eur J Clin Pharmacol. 1977 Dec 2;12(4):241-5. doi: 10.1007/BF00607422.
6
Studies on the mode of action of alpha-methyldopa.α-甲基多巴作用机制的研究。
Acta Physiol Scand Suppl. 1969;322:1-37.
7
Mechanism of action of methyldopa in the rat. Role of 3-O-methylated metabolites.甲基多巴在大鼠体内的作用机制。3 - O - 甲基化代谢物的作用
Circ Res. 1979 Nov;45(5):684-90. doi: 10.1161/01.res.45.5.684.
8
Site of action of methyldopa in lowering the blood pressure in man.甲基多巴在人体中降低血压的作用部位。
Clin Exp Pharmacol Physiol Suppl. 1978;4:11-5.
9
Antihypertensive effect of methyldopa in metacorticoid immunosympathectomized rats.
J Pharm Pharmacol. 1967 Jan;19(1):61-2. doi: 10.1111/j.2042-7158.1967.tb07998.x.
10
Evidence that the hypotensive action of methyldopa is mediated by central actions of methylnoradrenaline.
J Pharm Pharmacol. 1971 Jun;23(6):407-11. doi: 10.1111/j.2042-7158.1971.tb08671.x.

引用本文的文献

1
Effect of antihypertensive therapy with alpha methyldopa on levels of angiogenic factors in pregnancies with hypertensive disorders.α-甲基多巴降压治疗对妊娠高血压疾病患者血管生成因子水平的影响。
PLoS One. 2008 Jul 23;3(7):e2766. doi: 10.1371/journal.pone.0002766.
2
Disposition and pharmacodynamics of diuretics and antihypertensive agents in renal disease.肾病中利尿剂和抗高血压药物的处置及药效学
Eur J Clin Pharmacol. 1980 Jul;18(1):109-16. doi: 10.1007/BF00561487.
3
Studies on the mechanism of methyl-dopa-induced mydriasis in the cat.
Naunyn Schmiedebergs Arch Pharmacol. 1982 Jul;320(1):58-62. doi: 10.1007/BF00499073.
4
Alpha-methyl-DOPA induced mydriasis in the cat. Relationship between pupillary response and the oculomotor perfusate concentration of methyldopa and its metabolites.
Naunyn Schmiedebergs Arch Pharmacol. 1983 Nov;324(3):201-6. doi: 10.1007/BF00503895.
5
The influence of SK & F 64139, a phenylethanolamine-N-methyltransferase inhibitor, on centrally mediated cardiovascular effects of alpha-methyldopa and clonidine.苯乙醇胺-N-甲基转移酶抑制剂SK&F 64139对α-甲基多巴和可乐定中枢介导的心血管效应的影响。
Naunyn Schmiedebergs Arch Pharmacol. 1982 Dec;321(4):276-81. doi: 10.1007/BF00498513.
6
Central alpha- and beta-adrenoceptors modifying arterial blood pressure and heart rate in conscious cats.中枢α和β肾上腺素能受体对清醒猫动脉血压和心率的调节作用
Br J Pharmacol. 1974 Jul;51(3):325-33. doi: 10.1111/j.1476-5381.1974.tb10666.x.
7
alpha-Methyldopa produces mydriasis in the rat by stimulation of CNS alpha 2-adrenoceptors.α-甲基多巴通过刺激中枢神经系统α2-肾上腺素能受体在大鼠中产生散瞳作用。
Br J Pharmacol. 1988 Jul;94(3):834-8. doi: 10.1111/j.1476-5381.1988.tb11594.x.
8
Mechanism of L-alpha-methyldopa transport through a monolayer of polarized human intestinal epithelial cells (Caco-2).L-α-甲基多巴通过极化的人肠上皮细胞（Caco-2）单层转运的机制。
Pharm Res. 1990 Dec;7(12):1313-9. doi: 10.1023/a:1015906409585.
9
Hypotensive activity of S-alpha-methyldopa during long-term (steady-state) intravenous infusions.
J Pharmacokinet Biopharm. 1976 Oct;4(5):389-94. doi: 10.1007/BF01062828.
10
Centrally induced hypotension and bradycardia after administration of alpha-methylnoradrenaline into the area of the nucleus tractus solitarii of the rat.向大鼠孤束核区域注射α-甲基去甲肾上腺素后引起的中枢性低血压和心动过缓。
Br J Pharmacol. 1976 Dec;58(4):593-8. doi: 10.1111/j.1476-5381.1976.tb08628.x.