促甲状腺素释放因子的构象分析
Conformational analysis of thyrotropin releasing factor.
作者信息
Burgess A W, Momany F A, Scheraga H A
出版信息
Proc Natl Acad Sci U S A. 1973 May;70(5):1456-60. doi: 10.1073/pnas.70.5.1456.
Abstract
Conformational energy calculations on thyrotropin releasing factor and on several of its analogues indicate that the central histidyl residue of the native molecule is in an extended conformation. Some derivatives (with a reduced biological activity) have an altered conformation. Since some substitutions leave the conformation unchanged but alter the biological activity, these substitutions must involve the sites responsible for binding of the hormone to its receptor.
摘要
对促甲状腺激素释放因子及其几种类似物的构象能量计算表明，天然分子的中心组氨酸残基处于伸展构象。一些衍生物（生物活性降低）具有改变的构象。由于一些取代使构象保持不变但改变了生物活性，这些取代必定涉及负责激素与其受体结合的位点。
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引用本文的文献
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13C-nuclear magnetic resonance study of [85% 13C-enriched proline]thyrotropin releasing factor: 13C-13C vicinal coupling constants and conformation of the proline residue.[85% 13C富集脯氨酸]促甲状腺激素释放因子的13C核磁共振研究：脯氨酸残基的13C-13C邻位偶合常数及构象
Proc Natl Acad Sci U S A. 1975 Dec;72(12):4948-52. doi: 10.1073/pnas.72.12.4948.
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Stereochemical criteria for polypeptides and proteins. IV. Standard dimensions for the cis-peptide unit and conformation of cis-polypeptides.多肽和蛋白质的立体化学标准。IV. 顺式肽单元的标准尺寸和顺式多肽的构象
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Location of proline derivatives in conformational space. I. Conformational calculations; optical activity and NMR experiments.脯氨酸衍生物在构象空间中的位置。I. 构象计算；旋光性和核磁共振实验。
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Energy parameters in polypeptides. V. An empirical hydrogen bond potential function based on molecular orbital calculations.多肽中的能量参数。V. 基于分子轨道计算的经验氢键势函数。
J Phys Chem. 1972 Feb 3;76(3):375-93. doi: 10.1021/j100647a017.
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Synthesis of analogs of the thyrotropin-releasing hormone and structure-activity relationship.促甲状腺激素释放激素类似物的合成及其构效关系
J Med Chem. 1971 Jun;14(6):484-7. doi: 10.1021/jm00288a005.
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