7-氧杂和5-氧杂前列腺素类似物对前列腺素生物合成的抑制作用。
Inhibition of prostaglandin biosynthesis by 7-oxa- and 5-oxa-prostaglandin analogues.
作者信息
McDonald-Gibson R G, Flack J D, Ramwell P W
出版信息
Biochem J. 1973 Jan;132(1):117-20. doi: 10.1042/bj1320117.
Abstract
Some oxaprostaglandin derivatives have been shown to inhibit prostaglandin biosynthesis from arachidonate by a particulate prostaglandin synthetase preparation. The most potent inhibitor was 5-oxaprost-13-trans-enoate, and inhibition by this compound appeared to be competitive. Certain structure-activity relationships were ascertained.
摘要
一些氧前列素衍生物已被证明可通过微粒体前列腺素合成酶制剂抑制花生四烯酸生成前列腺素的生物合成。最有效的抑制剂是5-氧前列-13-反-烯酸酯，该化合物的抑制作用似乎具有竞争性。确定了某些构效关系。
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本文引用的文献
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THE BIOSYNTHESIS OF PROSTAGLANDIN E1 STUDIED WITH SPECIFICALLY 3H-LABELLED 8,11,14-EICOSATRIENOIC ACIDS.用特定的3H标记的8,11,14-二十碳三烯酸研究前列腺素E1的生物合成。
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Graphical analysis of single enzyme systems.单一酶系统的图形分析。
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The determination of enzyme inhibitor constants.酶抑制剂常数的测定
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The biological activities of three metabolites of prostaglandin E 1.前列腺素E1的三种代谢物的生物活性。
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Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids.油酸、亚油酸和亚麻酸对前列腺素合成的抑制作用。
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Enzyme inhibition by acetylenic compounds.炔属化合物对酶的抑制作用。
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9
Synthesis of (plus or minus)-7-oxaprostaglandin E1.（±）-7-氧杂前列腺素E1的合成
Tetrahedron Lett. 1970 Jun(31):2695-8. doi: 10.1016/s0040-4039(01)98315-7.
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