Kawamori R, Shichiri M, Murata T, Nomura M, Shigeta Y, Abe H
Acta Endocrinol (Copenh). 1979 Feb;90(2):283-94. doi: 10.1530/acta.0.0900283.
The dynamic property of insulin secretion in relation to glucose tolerance was investigated quantitatively during iv glucose tolerance tests in 237 cases. The following results were obtained; 1) Glucose clearance constant (k-value) was not constant but variable with time and should be expressed as a function of time, K(t). In normal glucose tolerance, K(t) became greater with time. 2) Glucose-induced insulin secretion was expressed as the function of a proportional plus derivative response to glucose concentration. A weighting function of derivative response, reflecting the insulin secretion per unit of rate of change in blood glucose concentration, was calculated from blood glucose concentration (input) and insulin concentration (output) by the deconvolution method. It was clearly shown that the gain in weighting function was small and the response was slow even in the individual whose glucose tolerance was slightly impaired. 3) The greater the weighting function, the larger the change in K(t).
在237例患者进行静脉葡萄糖耐量试验期间，对胰岛素分泌与葡萄糖耐量相关的动态特性进行了定量研究。得到以下结果：1）葡萄糖清除常数（k值）并非恒定不变，而是随时间变化的，应表示为时间的函数K(t)。在正常葡萄糖耐量情况下，K(t)随时间增加。2）葡萄糖诱导的胰岛素分泌表示为对葡萄糖浓度的比例加导数反应的函数。通过反卷积法从血糖浓度（输入）和胰岛素浓度（输出）计算出反映单位血糖浓度变化率的胰岛素分泌的导数反应加权函数。结果清楚表明，即使在葡萄糖耐量稍有受损的个体中，加权函数的增益也较小且反应缓慢。3）加权函数越大，K(t)的变化就越大。
