Bille-Brahe N E, Rørth M
Acta Obstet Gynecol Scand. 1979;58(1):19-21. doi: 10.3109/00016347909154906.
In normal, primigravidae red cell 2.3-diphosphoglycerate (2.3-DPG) concentration was found to be increased significantly from the third month of pregnancy. The 2.3-DPG concentration remained elevated throughout pregnancy. Increase in the 2.3-DPG concentration leads to a decrease in the oxygen affinity of the maternal red cells. The combination of low pCO2 and low oxygen affinity of the maternal blood facilitates the transport of oxygen as well as that of carbon dioxide across the placenta. The weight of the delivered children was not significantly correlated to the 2.3-DPG changes, and no significant variation of the measured variables could be detected in 9 women with abnormal pregnancies.
在正常情况下，初产妇红细胞2,3-二磷酸甘油酸（2,3-DPG）浓度从妊娠第三个月起显著升高。整个孕期2,3-DPG浓度一直保持升高。2,3-DPG浓度升高导致母体红细胞对氧的亲和力降低。母体血液中低pCO₂和低氧亲和力相结合，有利于氧和二氧化碳通过胎盘的转运。所分娩婴儿的体重与2,3-DPG的变化无显著相关性，并且在9例异常妊娠的妇女中未检测到所测变量的显著差异。
