Karam K, Hajj S
Acta Obstet Gynecol Scand. 1979;58(1):73-9. doi: 10.3109/00016347909154919.
Five patients were found to have hyperthecosis ovarii as evidenced by the presence of large lipid containing thecal cells in the ovarian stroma. The clinical picture was similar in all of them, featuring mild virilization, obesity and oligomenorrhea, with refractoriness to clomid therapy. Plasma FSH levels were low normal, while LH levels were slightly elevated. Urinary 17-ketosteroids levels were elevated, and plasma testosterone concentrations were upper normal. The response to dexamethasone suppression and HCG stimulation is discussed. The effect of wedge resection on the clinical and endocrinologic pictures is evaluated.
五名患者被发现患有卵巢泡膜细胞增生症，卵巢间质中存在大量含脂质的泡膜细胞可证明这一点。她们所有人的临床表现相似，具有轻度男性化、肥胖和月经过少的特点，对克罗米酚治疗无效。血浆促卵泡激素（FSH）水平处于正常低限，而促黄体生成素（LH）水平略有升高。尿17 - 酮类固醇水平升高，血浆睾酮浓度高于正常上限。讨论了地塞米松抑制和人绒毛膜促性腺激素（HCG）刺激的反应。评估了楔形切除术对临床和内分泌表现的影响。
