体内代谢物缩合反应。酒精代谢物与利多卡因代谢物反应生成N1-乙基-2-甲基-N3-(2,6-二甲基苯基)-4-咪唑啉酮。 - Suppr | 超能文献

In vivo metabolite condensations. Formation of N1-ethyl-2-methyl-N3-(2,6-dimethylphenyl)-4-imidazolidinone from the reaction of a metabolite of alcohol with a metabolite of lidocaine.

作者信息

Nelson S D, Breck G D, Trager W F

出版信息

J Med Chem. 1973 Oct;16(10):1106-12. doi: 10.1021/jm00268a009.

DOI:10.1021/jm00268a009

Abstract

摘要

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In vivo metabolite condensations. Formation of N1-ethyl-2-methyl-N3-(2,6-dimethylphenyl)-4-imidazolidinone from the reaction of a metabolite of alcohol with a metabolite of lidocaine.体内代谢物缩合反应。酒精代谢物与利多卡因代谢物反应生成N1-乙基-2-甲基-N3-(2,6-二甲基苯基)-4-咪唑啉酮。

J Med Chem. 1973 Oct;16(10):1106-12. doi: 10.1021/jm00268a009.

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Primary and beta-secondary deuterium isotope effects in N-deethylation reactions.N-去乙基化反应中的一级和β-二级氘同位素效应。

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Identification of glycinexylidide in patients treated with intravenous lidocaine.静脉注射利多卡因治疗患者中甘氨酰利多卡因的鉴定。

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Quantification of lidocaine and several metabolites utilizing chemical-ionization mass spectrometry and stable isotope labeling.利用化学电离质谱法和稳定同位素标记对利多卡因及几种代谢物进行定量分析。

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Lack of evidence for the formation of N-hydroxyamide metabolites of lidocaine in man.缺乏利多卡因在人体内形成N-羟基酰胺代谢物的证据。

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