氧化N-脱烷基化：人体内利多卡因新代谢产物形成过程中的一个曼尼希中间体。
Oxidative N-dealkylation: a mannich intermediate in the formation of a new metabolite of lidocaine in man.
作者信息
Breck G D, Trager W F
出版信息
Science. 1971 Aug 6;173(3996):544-6. doi: 10.1126/science.173.3996.544.
PMID:5564044
Abstract
Evidence is presented for a new metabolite of lidocaine. Its structure, N(1)-ethyl-2-methyl-N(3)-(2,6-dimethylphenyl)-4-imidazolidinone, suggests reactive electrophilic intermediates for the oxidative removal of N-alkyl groups in general.
摘要
有证据表明利多卡因存在一种新的代谢物。其结构为N(1)-乙基-2-甲基-N(3)-(2,6-二甲基苯基)-4-咪唑啉酮，这表明一般来说，氧化去除N-烷基的反应性亲电中间体存在。
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