大脑中动脉闭塞前后对颈内动脉注射5-羟色胺的脑血管反应。
Cerebrovascular response to intracarotid injection of serotonin before and after middle cerebral artery occlusion.
作者信息
Welch K M, Hashi K, Meyer J S
出版信息
J Neurol Neurosurg Psychiatry. 1973 Oct;36(5):724-35. doi: 10.1136/jnnp.36.5.724.
Abstract
The effect of intracarotid injection of serotonin (5-HT) on internal carotid artery flow and oxygen availability (O(2)a) of the cerebral cortex was studied in 10 baboons. Vasoconstriction occurred in the vascular bed of the territory supplied by the injected artery. After one middle cerebral artery was occluded the vasoconstrictor effect of 5-HT was more pronounced, particularly in the non-ischaemic hemisphere. The capacity of the cerebral vessels to provide collateral blood flow was reduced in both ischaemic and non-ischaemic areas of brain. As a result of focal cerebral ischaemia, 5-HT may accumulate in the brain and contribute to the progression of infarction.
摘要
在10只狒狒身上研究了颈内注射5-羟色胺（5-HT）对颈内动脉血流及大脑皮质氧供应（O₂a）的影响。注射动脉所供应区域的血管床发生了血管收缩。在一侧大脑中动脉闭塞后，5-HT的血管收缩效应更为明显，尤其是在非缺血半球。大脑血管提供侧支血流的能力在脑缺血和非缺血区域均降低。由于局灶性脑缺血，5-HT可能在脑内蓄积并促使梗死进展。
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