Calamera J C, Morgenfeld M C, Mancini R E, Vilar O
Andrologia. 1979 Jan;11(1):43-50. doi: 10.1111/j.1439-0272.1979.tb02158.x.
Biochemical analysis and morphological studies were carried out in six patients with lymphomas during and after withdrawal treatment with chlorambucil, testosterone propionate (TP) and human chorionic gonadotropins (HCG). In the course of the treatment with chlorambucil patients developed severe oligozoospermia or azoospermia. The spermatogenesis recovered after a variable period of time following suspension of treatment. During the drug administration seminal fructose and citric acid concentrations increase but the recovery after withdrawal takes a longer period of time. Simultaneous treatment with HCG or TP normalized the biochemical parameters without restoring spermatogenesis.
对6例淋巴瘤患者在使用苯丁酸氮芥、丙酸睾酮（TP）和人绒毛膜促性腺激素（HCG）治疗期间及停药后进行了生化分析和形态学研究。在使用苯丁酸氮芥治疗过程中，患者出现严重少精子症或无精子症。停药后经过不同时间段，精子发生得以恢复。用药期间精液果糖和柠檬酸浓度升高，但停药后的恢复需要更长时间。同时使用HCG或TP可使生化参数恢复正常，但不能恢复精子发生。
