枯草芽孢杆菌中乌头酸酶合成的调控：诱导、反馈阻遏和分解代谢物阻遏。
Regulation of aconitase synthesis in Bacillus subtilis: induction, feedback repression, and catabolite repression.
作者信息
Ohné M
出版信息
J Bacteriol. 1974 Mar;117(3):1295-305. doi: 10.1128/jb.117.3.1295-1305.1974.
Abstract
The synthesis of aconitase in Bacillus subtilis wild-type and different citric acid cycle mutants has been studied and the influence of various growth conditions examined. Aconitase is induced by citrate and precursors of citrate and repressed by glutamate. Induction and repression counteract each other, and at equimolar concentrations of citrate and glutamate, aconitase synthesis is unaffected. Induction by citrate can partly overcome catabolite repression of aconitase. Isocitrate dehydrogenase show endogenous induction of aconitase due to citrate accumulation. Leaky mutants defective in citrate synthase and aconitase cannot be induced by citrate, which indicates that they carry a regulatory mutation. The complex regulation of aconitase is discussed with reference to the participation of this enzyme in glutamate biosynthesis and energy metabolism.
摘要
对枯草芽孢杆菌野生型及不同柠檬酸循环突变体中乌头酸酶的合成进行了研究，并考察了各种生长条件的影响。乌头酸酶由柠檬酸盐及柠檬酸盐前体诱导产生，并受谷氨酸抑制。诱导和抑制相互抵消，在柠檬酸盐和谷氨酸等摩尔浓度下，乌头酸酶的合成不受影响。柠檬酸盐诱导可部分克服乌头酸酶的分解代谢阻遏。由于柠檬酸盐积累，异柠檬酸脱氢酶显示出乌头酸酶的内源性诱导。柠檬酸合酶和乌头酸酶有缺陷的渗漏突变体不能被柠檬酸盐诱导，这表明它们携带调控突变。参照该酶在谷氨酸生物合成和能量代谢中的参与情况，对乌头酸酶的复杂调控进行了讨论。
相似文献
1
Regulation of aconitase synthesis in Bacillus subtilis: induction, feedback repression, and catabolite repression.枯草芽孢杆菌中乌头酸酶合成的调控：诱导、反馈阻遏和分解代谢物阻遏。
J Bacteriol. 1974 Mar;117(3):1295-305. doi: 10.1128/jb.117.3.1295-1305.1974.
2
Developmental block in citric acid cycle mutants of Bacillus subtilis.枯草芽孢杆菌柠檬酸循环突变体中的发育阻滞
J Bacteriol. 1973 Dec;116(3):1466-8. doi: 10.1128/jb.116.3.1466-1468.1973.
3
Catabolite repression of aconitate hydratase in Bacillus subtilis.枯草芽孢杆菌中乌头酸水合酶的分解代谢物阻遏
Biochim Biophys Acta. 1968 Apr 16;158(1):36-44. doi: 10.1016/0304-4165(68)90069-x.
4
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.2-酮戊二酸与枯草芽孢杆菌中乌头酸酶和组氨酸酶形成的调节
J Bacteriol. 1984 Apr;158(1):379-82. doi: 10.1128/jb.158.1.379-382.1984.
5
Induction of citric acid cycle enzymes during initiation of sporulation by guanine nucleotide deprivation.鸟嘌呤核苷酸剥夺诱导芽孢形成起始过程中柠檬酸循环酶的产生。
J Bacteriol. 1981 Apr;146(1):337-44. doi: 10.1128/jb.146.1.337-344.1981.
6
Effect of boseimycin on some enzyme systems of Bacillus subtilis.波塞霉素对枯草芽孢杆菌某些酶系统的影响。
Folia Microbiol (Praha). 1975;20(2):124-9. doi: 10.1007/BF02876768.
7
Anaerobic regulation of Bacillus subtilis Krebs cycle genes.枯草芽孢杆菌三羧酸循环基因的厌氧调控
J Bacteriol. 1998 Jul;180(13):3304-11. doi: 10.1128/JB.180.13.3304-3311.1998.
8
Isolation of mutants of Bacillus stearothermophilus blocked in catabolic function.分离在分解代谢功能方面受阻的嗜热脂肪芽孢杆菌突变体。
Can J Microbiol. 1973 Dec;19(12):1521-3. doi: 10.1139/m73-249.
9
Effect of different nutritional conditions on the synthesis of tricarboxylic acid cycle enzymes.不同营养条件对三羧酸循环酶合成的影响。
J Bacteriol. 1967 Jun;93(6):1777-87. doi: 10.1128/jb.93.6.1777-1787.1967.
10
Regulation of the dicarboxylic acid part of the citric acid cycle in Bacillus subtilis.枯草芽孢杆菌中柠檬酸循环二羧酸部分的调控
J Bacteriol. 1975 Apr;122(1):224-34. doi: 10.1128/jb.122.1.224-234.1975.
引用本文的文献
1
Complex regulation of the Bacillus subtilis aconitase gene.枯草芽孢杆菌乌头酸酶基因的复杂调控
J Bacteriol. 2003 Mar;185(5):1672-80. doi: 10.1128/JB.185.5.1672-1680.2003.
2
Roles of aconitase in growth, metabolism, and morphological differentiation of Streptomyces coelicolor.乌头酸酶在天蓝色链霉菌生长、代谢及形态分化中的作用
J Bacteriol. 2001 May;183(10):3193-203. doi: 10.1128/JB.183.10.3193-3203.2001.
3
Catabolite repression and induction of the Mg(2+)-citrate transporter CitM of Bacillus subtilis.枯草芽孢杆菌Mg(2+) - 柠檬酸盐转运蛋白CitM的分解代谢物阻遏与诱导
J Bacteriol. 2000 Nov;182(21):6099-105. doi: 10.1128/JB.182.21.6099-6105.2000.
4
Anaerobic regulation of Bacillus subtilis Krebs cycle genes.枯草芽孢杆菌三羧酸循环基因的厌氧调控
J Bacteriol. 1998 Jul;180(13):3304-11. doi: 10.1128/JB.180.13.3304-3311.1998.
5
A null mutation in the Bacillus subtilis aconitase gene causes a block in Spo0A-phosphate-dependent gene expression.枯草芽孢杆菌顺乌头酸酶基因的无效突变导致Spo0A-磷酸依赖型基因表达受阻。
J Bacteriol. 1997 Dec;179(23):7351-9. doi: 10.1128/jb.179.23.7351-7359.1997.
6
Identification and characterization of the ccdA gene, required for cytochrome c synthesis in Bacillus subtilis.枯草芽孢杆菌中细胞色素c合成所需的ccdA基因的鉴定与表征。
J Bacteriol. 1997 Mar;179(6):1962-73. doi: 10.1128/jb.179.6.1962-1973.1997.
7
Rhizobium tropici chromosomal citrate synthase gene.热带根瘤菌染色体柠檬酸合酶基因
Appl Environ Microbiol. 1995 Nov;61(11):3992-7. doi: 10.1128/aem.61.11.3992-3997.1995.
8
Synthesis of oxaloacetate in Bacillus subtilis mutants lacking the 2-ketoglutarate dehydrogenase enzymatic complex.枯草芽孢杆菌中缺乏2-酮戊二酸脱氢酶复合体的突变体中草酰乙酸的合成。
J Bacteriol. 1984 Apr;158(1):55-62. doi: 10.1128/jb.158.1.55-62.1984.
9
2-Ketoglutarate and the regulation of aconitase and histidase formation in Bacillus subtilis.2-酮戊二酸与枯草芽孢杆菌中乌头酸酶和组氨酸酶形成的调节
J Bacteriol. 1984 Apr;158(1):379-82. doi: 10.1128/jb.158.1.379-382.1984.
10
Sporulation properties of cytochrome a-deficient mutants of Bacillus subtilis.枯草芽孢杆菌细胞色素a缺陷型突变体的芽孢形成特性
J Bacteriol. 1974 Dec;120(3):1004-11. doi: 10.1128/jb.120.3.1004-1011.1974.
本文引用的文献
1
TRANSFORMATION OF BIOCHEMICALLY DEFICIENT STRAINS OF BACILLUS SUBTILIS BY DEOXYRIBONUCLEATE.脱氧核糖核酸对枯草芽孢杆菌生化缺陷菌株的转化
Proc Natl Acad Sci U S A. 1958 Oct 15;44(10):1072-8. doi: 10.1073/pnas.44.10.1072.
2
REQUIREMENTS FOR TRANSFORMATION IN BACILLUS SUBTILIS.枯草芽孢杆菌转化的要求。
J Bacteriol. 1961 May;81(5):741-6. doi: 10.1128/jb.81.5.741-746.1961.
3
Requirement for Acetate and Glycine (or Serine) for Sporulation Without Growth of Bacillus subtilis.枯草芽孢杆菌不生长时芽孢形成对乙酸盐和甘氨酸（或丝氨酸）的需求
J Bacteriol. 1970 Dec;104(3):1074-85. doi: 10.1128/jb.104.3.1074-1085.1970.
4
Spectrophotometric measurements of the enzymatic formation of fumaric and cis-aconitic acids.富马酸和顺乌头酸酶促形成的分光光度测量。
Biochim Biophys Acta. 1950 Jan;4(1-3):211-4. doi: 10.1016/0006-3002(50)90026-6.
5
Protein measurement with the Folin phenol reagent.使用福林酚试剂进行蛋白质测定。
J Biol Chem. 1951 Nov;193(1):265-75.
6
LINKAGE RELATIONSHIPS OF GENES CONTROLLING ISOLEUCINE, VALINE, AND LEUCINE BIOSYNTHESIS IN BACILLUS SUBTILIS.枯草芽孢杆菌中控制异亮氨酸、缬氨酸和亮氨酸生物合成的基因的连锁关系
J Bacteriol. 1965 Aug;90(2):357-69. doi: 10.1128/jb.90.2.357-369.1965.
7
REVERSIBLE DISRUPTION OF A WAVELENGTH DISCRIMINATION IN PIGEONS FOLLOWING ADMINISTRATION OF PHENIPRAZINE.苯乙肼给药后鸽子波长辨别能力的可逆性破坏
Toxicol Appl Pharmacol. 1964 Nov;6:690-5. doi: 10.1016/0041-008x(64)90119-x.
8
THE DEVELOPMENTAL SIGNIFICANCE OF ALANINE DEHYDROGENASE IN BACILLUS SUBTILIS.枯草芽孢杆菌中丙氨酸脱氢酶的发育意义
Proc Natl Acad Sci U S A. 1964 Jun;51(6):1164-72. doi: 10.1073/pnas.51.6.1164.
9
THE ROLES OF INDUCER AND CATABOLITE REPRESSOR IN THE SYNTHESIS OF BETA-GALACTOSIDASE BY ESCHERICHIA COLI.诱导物和分解代谢物阻遏物在大肠杆菌β-半乳糖苷酶合成中的作用
J Mol Biol. 1964 Jan;8:105-27. doi: 10.1016/s0022-2836(64)80153-4.
10
A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid.用于比色法测定脱氧核糖核酸的二苯胺反应的条件及机制研究。
Biochem J. 1956 Feb;62(2):315-23. doi: 10.1042/bj0620315.
Zotero 插件