枯草芽孢杆菌中乌头酸酶合成的调控：诱导、反馈阻遏和分解代谢物阻遏。
Regulation of aconitase synthesis in Bacillus subtilis: induction, feedback repression, and catabolite repression.
作者信息
Ohné M
出版信息
J Bacteriol. 1974 Mar;117(3):1295-305. doi: 10.1128/jb.117.3.1295-1305.1974.
Abstract
The synthesis of aconitase in Bacillus subtilis wild-type and different citric acid cycle mutants has been studied and the influence of various growth conditions examined. Aconitase is induced by citrate and precursors of citrate and repressed by glutamate. Induction and repression counteract each other, and at equimolar concentrations of citrate and glutamate, aconitase synthesis is unaffected. Induction by citrate can partly overcome catabolite repression of aconitase. Isocitrate dehydrogenase show endogenous induction of aconitase due to citrate accumulation. Leaky mutants defective in citrate synthase and aconitase cannot be induced by citrate, which indicates that they carry a regulatory mutation. The complex regulation of aconitase is discussed with reference to the participation of this enzyme in glutamate biosynthesis and energy metabolism.
摘要
对枯草芽孢杆菌野生型及不同柠檬酸循环突变体中乌头酸酶的合成进行了研究，并考察了各种生长条件的影响。乌头酸酶由柠檬酸盐及柠檬酸盐前体诱导产生，并受谷氨酸抑制。诱导和抑制相互抵消，在柠檬酸盐和谷氨酸等摩尔浓度下，乌头酸酶的合成不受影响。柠檬酸盐诱导可部分克服乌头酸酶的分解代谢阻遏。由于柠檬酸盐积累，异柠檬酸脱氢酶显示出乌头酸酶的内源性诱导。柠檬酸合酶和乌头酸酶有缺陷的渗漏突变体不能被柠檬酸盐诱导，这表明它们携带调控突变。参照该酶在谷氨酸生物合成和能量代谢中的参与情况，对乌头酸酶的复杂调控进行了讨论。
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