Satterfield J H, Cantwell D P, Schell A, Blaschke T
Arch Gen Psychiatry. 1979 Feb;36(2):212-7. doi: 10.1001/archpsyc.1979.01780020102011.
This is a study of the growth of 72 hyperactive boys treated continuously with methylphenidate hydrochloride. Major findings were that methylphenidate produces an adverse effect on growth in height and in weight in the first year of treatment, but not in the second year; the first year height deficit is offset in the second year by a greater-than-expected growth rate. No clinical predictors of growth deficits were found; growth in height deficits are not related to total dosage or summer drug holidays, but weight deficits may be related to these factors. Side effects did not correlate with dosage. The temporary growth deficits of the first year are of such minor magnitude as to have little clinical significance.
这是一项关于72名持续接受盐酸哌甲酯治疗的多动男孩生长情况的研究。主要研究结果如下：在治疗的第一年，哌甲酯对身高和体重增长产生不良影响，但在第二年则没有；第一年的身高不足在第二年被高于预期的生长速度所抵消。未发现生长不足的临床预测因素；身高不足与总剂量或夏季停药期无关，但体重不足可能与这些因素有关。副作用与剂量无关。第一年的暂时性生长不足程度较轻，临床意义不大。
