Silverman M, Konig P, Godfrey S
Thorax. 1973 Sep;28(5):574-8. doi: 10.1136/thx.28.5.574.
, , 574-578. A technique for studying the efficacy and duration of action of drugs used in asthma by means of exercise tests is described. The patient runs for six minutes every two hours, four times a day, on a treadmill at a constant speed and slope. The test drug or its placebo is given immediately before the first test of the day, and their effects on the exercise-induced asthma are compared. This enables the immediate protection and duration of action of the test drug to be measured. No change in the severity of post-exercise asthma was found when serial tests were performed during one day after administration of a placebo. In a selected group of 14 children studied with disodium cromoglycate, three patterns were seen. In five patients the drug afforded prolonged benefit, in five others the protection was very short-lived, and in four patients it did not seem to be better than the placebo. The use of the tests is also illustrated with respect to bronchodilator drugs.
描述了一种通过运动试验研究用于哮喘的药物疗效和作用持续时间的技术。患者每天在跑步机上以恒定速度和坡度每两小时跑六分钟，共跑四次。在当天的首次试验前立即给予试验药物或其安慰剂，并比较它们对运动诱发哮喘的影响。这使得能够测量试验药物的即时保护作用和作用持续时间。给予安慰剂后在一天内进行系列试验时，运动后哮喘的严重程度没有变化。在一组选定的14名使用色甘酸钠进行研究的儿童中，观察到三种模式。在五名患者中，药物提供了长期益处；在另外五名患者中，保护作用非常短暂；在四名患者中，药物似乎并不比安慰剂更好。还举例说明了这些试验在支气管扩张剂药物方面的应用。
