Seller M J, Embury S, Polani P E, Adinolfi M
Proc R Soc Lond B Biol Sci. 1979 Nov 30;206(1162):95-107. doi: 10.1098/rspb.1979.0093.
Vitamin A, a known teratogen of the central nervous system, was administered in various doses, at the time of active neural tube closure, to pregnant curly-tail mice which have a genetic predisposition to neural tube defects (n.t.d.), and to A Strong mice, which are not so predisposed. The curly-tail mice showed an enhanced susceptibility to the teratogenic effect of vitamin A given on day 8 of gestation, demonstrating a clear gene-environment interaction. There was a differential response by the two sexes. Females seemed to be more affected by the vitamin A than males. When vitamin A was administered on day 9, instead of day 8, of gestation, the incidence of n.t.d. decreased rather than increased. Furthermore, the number of mice affected by n.t.d. was markedly lower even than that found spontaneously in untreated curly-tail mice.
维生素A是一种已知的中枢神经系统致畸剂，在神经管主动闭合期间，以不同剂量给予具有神经管缺陷（NTD）遗传易感性的怀孕卷尾小鼠，以及不具有这种易感性的A Strong小鼠。卷尾小鼠对妊娠第8天给予的维生素A致畸作用表现出更高的易感性，表明存在明显的基因-环境相互作用。两性有不同的反应。雌性似乎比雄性受维生素A的影响更大。当在妊娠第9天而不是第8天给予维生素A时，神经管缺陷的发生率降低而不是增加。此外，受神经管缺陷影响的小鼠数量甚至明显低于未治疗的卷尾小鼠自发出现的数量。
