Moellering R C, Medoff G, Leech I, Wennersten C, Kunz L J
Antimicrob Agents Chemother. 1972 Jan;1(1):30-4. doi: 10.1128/AAC.1.1.30.
The effectiveness of ampicillin, penicillin, streptomycin, and gentamicin against 20 strains of Listeria monocytogenes was studied in vitro. For all strains, the minimal bactericidal concentration (MBC) of both ampicillin and penicillin was much higher than the minimal inhibitory concentration (MIC). The MBC of both streptomycin and gentamicin was close to the MIC, but relatively high concentrations of these antibiotics were necessary to inhibit the growth of most of the strains of Listeria. The combination of penicillin plus streptomycin was synergistic against 19 of 20 strains and in the remaining strain produced enhanced killing (but of less magnitude than our criterion for synergism). Combinations of penicillin plus gentamicin, ampicillin plus streptomycin, and ampicillin plus gentamicin produced enhanced killing against all strains tested. No antagonism was observed when ampicillin or penicillin was combined with streptomycin or gentamicin.
体外研究了氨苄西林、青霉素、链霉素和庆大霉素对20株单核细胞增生李斯特菌的有效性。对于所有菌株，氨苄西林和青霉素的最低杀菌浓度（MBC）远高于最低抑菌浓度（MIC）。链霉素和庆大霉素的MBC接近MIC，但需要相对高浓度的这些抗生素才能抑制大多数李斯特菌菌株的生长。青霉素加链霉素的组合对20株中的19株具有协同作用，在其余菌株中产生增强的杀菌作用（但程度低于我们的协同作用标准）。青霉素加庆大霉素、氨苄西林加链霉素以及氨苄西林加庆大霉素的组合对所有测试菌株均产生增强的杀菌作用。当氨苄西林或青霉素与链霉素或庆大霉素联合使用时，未观察到拮抗作用。
