对抗叶酸抗疟化合物的交叉耐药性和附带敏感性。
Cross-resistance and collateral susceptibility to antifolic antimalarial compounds.
作者信息
Smith C C, Genther C S
出版信息
Antimicrob Agents Chemother. 1972 Sep;2(3):103-8. doi: 10.1128/AAC.2.3.103.
Series of strains of Streptococcus faecium ATCC 8043, Lactobacillus casei ATCC 7469, and Pediococcus cerevisiae ATCC 8081 with increasing resistance to the active antifolate antimalarial drugs chlorguanide triazine (CGT), pyrimethamine (PM), and trimethoprim (TMP) were isolated. These mutant strains, stable for at least 3 to 5 years, were examined for cross-resistance and collateral susceptibility to the above compounds and to methotrexate (MTX). Generally, they exhibited cross-resistance to all four compounds, but resistance of a strain to one compound did not predict accurately its resistance to another drug. Unexpectedly, L. casei resistant to CGT exhibited collateral susceptibility to MTX, TMP, and PM varying from 5- to 20-fold. P. cerevisiae developed resistance to CGT readily but maintained its susceptibility to PM and TMP after prolonged exposure to these compounds. Resistance to these antimalarial antifolates was accompanied by only low-grade cross-resistance to MTX, a representative antileukemic antifolate agent.
分离出了粪肠球菌ATCC 8043、干酪乳杆菌ATCC 7469和酿酒片球菌ATCC 8081对活性抗叶酸抗疟药物氯胍三嗪（CGT）、乙胺嘧啶（PM）和甲氧苄啶（TMP）耐药性不断增加的一系列菌株。对这些至少稳定3至5年的突变菌株进行了对上述化合物和甲氨蝶呤（MTX）的交叉耐药性和附带敏感性检测。一般来说，它们对所有四种化合物都表现出交叉耐药性，但一个菌株对一种化合物的耐药性并不能准确预测其对另一种药物的耐药性。出乎意料的是，对CGT耐药的干酪乳杆菌对MTX、TMP和PM表现出5至20倍不等的附带敏感性。酿酒片球菌很容易对CGT产生耐药性，但在长时间接触这些化合物后仍保持对PM和TMP的敏感性。对这些抗疟抗叶酸药物的耐药性仅伴随着对MTX（一种代表性的抗白血病抗叶酸药物）的低度交叉耐药性。
Zotero 插件