• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Irreversible binding of ethynyl-estradiol metabolites to protein and nucleic acids as catalyzed by rat liver microsomes and mushroom tyrosinase.

作者信息

Bolt H M, Kappus H

出版信息

J Steroid Biochem. 1974 Apr;5(2):179-84. doi: 10.1016/0022-4731(74)90126-5.

DOI:10.1016/0022-4731(74)90126-5
PMID:4210249
Abstract
摘要

相似文献

1
Irreversible binding of ethynyl-estradiol metabolites to protein and nucleic acids as catalyzed by rat liver microsomes and mushroom tyrosinase.大鼠肝脏微粒体和蘑菇酪氨酸酶催化乙炔雌二醇代谢物与蛋白质和核酸的不可逆结合。
J Steroid Biochem. 1974 Apr;5(2):179-84. doi: 10.1016/0022-4731(74)90126-5.
2
Proceedings: Catalysis of the covalent binding of estrogens to macromolecules by liver microsomes as compared with the model enzyme tyrosinase.论文：与模型酶酪氨酸酶相比，肝脏微粒体对雌激素与大分子共价结合的催化作用。
Naunyn Schmiedebergs Arch Pharmacol. 1974;282(Suppl):suppl 282:R45.
3
The carcinogenic activity of ethinyl estrogens is determined by both their hormonal characteristics and their conversion to catechol metabolites.乙炔基雌激素的致癌活性由其激素特性及其向儿茶酚代谢物的转化共同决定。
Endocrinology. 1993 Feb;132(2):577-83. doi: 10.1210/endo.132.2.8381068.
4
Estrogen metabolism in rat liver microsomal and isolated hepatocyte preparations--II. Inhibition studies.大鼠肝微粒体和分离肝细胞制剂中的雌激素代谢——II. 抑制研究。
J Steroid Biochem. 1984 Dec;21(6):709-16. doi: 10.1016/0022-4731(84)90035-9.
5
Covalent binding of estrogen metabolites to hamster liver microsomal proteins: inhibition by ascorbic acid and catechol-O-methyl transferase.雌激素代谢产物与仓鼠肝脏微粒体蛋白的共价结合：抗坏血酸和儿茶酚-O-甲基转移酶的抑制作用
Carcinogenesis. 1987 Feb;8(2):209-15. doi: 10.1093/carcin/8.2.209.
6
Irreversible binding of ethynylestradiol metabolites to protein: lack of methylation by S-adenosyl-methionine.乙炔雌二醇代谢物与蛋白质的不可逆结合：S-腺苷甲硫氨酸缺乏甲基化作用。
Horm Metab Res. 1974 Jul;6(4):333-4. doi: 10.1055/s-0028-1095716.
7
The urinary metabolites of 17alpha-ethynylestradiol-9alpha,11xi-3H in women. Chromatographic profiling and indentification of ethynyl and non-ethynyl compounds.17α-乙炔雌二醇-9α,11ξ-³H在女性体内的尿液代谢产物。乙炔基和非乙炔基化合物的色谱分析及鉴定
Steroids. 1975 Feb;25(2):229-46. doi: 10.1016/s0039-128x(75)90135-x.
8
Metabolism of 17 alpha-ethinylestradiol by human liver microsomes in vitro: aromatic hydroxylation and irreversible protein binding of metabolites.人肝微粒体体外对17α-乙炔雌二醇的代谢：代谢产物的芳香族羟基化和不可逆蛋白结合
J Clin Endocrinol Metab. 1974 Dec;39(6):1072-80. doi: 10.1210/jcem-39-6-1072.
9
4-Hydroxyestradiol is conjugated with thiols primarily at C-2: evidence from regiospecific displacement of tritium by rat liver microsomes or tyrosinase.4-羟基雌二醇主要在C-2位与硫醇结合：来自大鼠肝脏微粒体或酪氨酸酶对氚的区域特异性取代的证据。
Steroids. 1988 Mar-Apr;51(3-4):395-409. doi: 10.1016/0039-128x(88)90027-x.
10
Estrogen 1,2-epoxides or estrogen quinones/semiquinones.雌激素1,2 - 环氧化物或雌激素醌/半醌。
Biochem Biophys Res Commun. 1985 Dec 31;133(3):1078-85. doi: 10.1016/0006-291x(85)91246-x.

引用本文的文献

1
Covalent binding of drug metabolites to DNA--a tool of predictive value?药物代谢产物与DNA的共价结合——一种具有预测价值的工具？
Arch Toxicol. 1980 Nov;46(1-2):171-80. doi: 10.1007/BF00361255.
2
Interaction of estrone and estradiol with DNA and protein of liver and kidney in rat and hamster in vivo and in vitro.雌酮和雌二醇在大鼠和仓鼠体内及体外与肝脏和肾脏的DNA和蛋白质的相互作用。
Arch Toxicol. 1984 Jul;55(2):97-103. doi: 10.1007/BF00346046.
3
Metabolism of stilbene estrogens and steroidal estrogens in relation to carcinogenicity.芪类雌激素和甾体雌激素的代谢与致癌性的关系。
Arch Toxicol. 1984 Jul;55(2):104-9. doi: 10.1007/BF00346047.
4
The metabolism of 17 alpha-ethinyloestradiol by human liver microsomes: formation of catechol and chemically reactive metabolites.人肝微粒体对17α-乙炔雌二醇的代谢：儿茶酚及化学反应性代谢产物的形成
Br J Clin Pharmacol. 1987 Apr;23(4):447-53. doi: 10.1111/j.1365-2125.1987.tb03074.x.
5
Semiquinone anion radicals of catechol(amine)s, catechol estrogens, and their metal ion complexes.儿茶酚（胺）、儿茶酚雌激素及其金属离子络合物的半醌阴离子自由基。
Environ Health Perspect. 1985 Dec;64:185-98. doi: 10.1289/ehp.8564185.
6
Effect of rifampicin treatment on the metabolism of oestradiol and 17alpha-ethinyloestradiol by human liver microsomes.利福平治疗对人肝微粒体中雌二醇和17α-乙炔雌二醇代谢的影响。
Eur J Clin Pharmacol. 1975 Jun 13;8(5):301-7. doi: 10.1007/BF00562654.
7
Decreased liver cytochrome P-450 in rats caused by norethindrone or ethynyloestradiol.炔诺酮或炔雌醇导致大鼠肝脏细胞色素P - 450减少。
Biochem J. 1977 Jul 15;166(1):57-64. doi: 10.1042/bj1660057.
8
Irreversible binding of 3-14C-antipyrine to hepatic protein in vivo and in metabolizing liver microsomes.3-¹⁴C-安替比林在体内及代谢性肝微粒体中与肝蛋白的不可逆结合。
Naunyn Schmiedebergs Arch Pharmacol. 1977 Mar;297(1):105-10. doi: 10.1007/BF00508817.
9
Metabolic activation of acetylenic substituents to derivatives in the rat causing the loss of hepatic cytochrome P-450 and haem.大鼠体内乙炔取代基代谢活化为衍生物，导致肝细胞色素P-450和血红素丧失。
Biochem J. 1978 Sep 15;174(3):853-61. doi: 10.1042/bj1740853.
10
The significance of covalent binding of catechols to proteins in vivo.儿茶酚在体内与蛋白质共价结合的意义。
Arch Toxicol. 1977 Dec 30;39(1-2):31-9. doi: 10.1007/BF00343273.