抗肿瘤药物N-（膦酰乙酰基）-L-天冬氨酸（PALA）的酶活性测定
Enzymatic assay for the antitumor agent-N-(phosphonacetyl)-L-aspartic acid (PALA).
作者信息
Friedman J, Moore E C, Hall S W, Loo T L
出版信息
Cancer Treat Rep. 1979 Jan;63(1):85-8.
PMID:421235
Abstract
A method is described for the assay of N-(phosphonacetyl)-L-aspartic acid in plasma or urine, based on inhibition of partially purified aspartate carbamoyltransferase from rat liver. Concentrations of N-(phosphonacetyl)-L-aspartic acid as low as 0.1 microgram/ml can be detected. Plasma disappearance and urinary excretion curves from one patient are shown as examples of the application of the method.
摘要
本文描述了一种基于抑制大鼠肝脏部分纯化的天冬氨酸氨甲酰转移酶来测定血浆或尿液中N-（膦酰基乙酰基）-L-天冬氨酸的方法。低至0.1微克/毫升的N-（膦酰基乙酰基）-L-天冬氨酸浓度都能被检测到。给出了一位患者的血浆清除曲线和尿排泄曲线，作为该方法应用的示例。
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