Ehrly A M, Landgraft H, Saeger-Lorenz K, Wodniok M
Dtsch Med Wochenschr. 1979 Feb 9;104(6):218-22. doi: 10.1055/s-0028-1103873.
The possible effect of xipamide on flow properties of blood were studied in groups of eight patients each with essential hypertension. It was demonstrated that 10 mg xipamide (a long-acting diuretic) given daily had no deleterious effect on flow property, while 20 mg daily produced a haemoconcentration which negatively affected it, apparently in relation to the urine volume excreted per unit time. At higher dosages the effect on blood flow properties was shifted in time, which indicates that the increased diuresis in the first day leads to a cumulative effect on the flow properties of the blood. Erythrocyte deformability was not affected. It is possible that combined preparations which contain a diuretic should be specially examined with respect to any undesirable effect on flow properties of the blood.
在每组八名原发性高血压患者中研究了氯噻嗪对血液流动特性的可能影响。结果表明，每天服用10毫克氯噻嗪（一种长效利尿剂）对血液流动特性没有有害影响，而每天服用20毫克会导致血液浓缩，对其产生负面影响，这显然与单位时间内排出的尿量有关。在更高剂量下，对血流特性的影响在时间上发生了变化，这表明第一天利尿增加会对血液流动特性产生累积效应。红细胞变形性未受影响。含有利尿剂的复方制剂可能应特别检查其对血液流动特性的任何不良影响。
