球形红假单胞菌中由4,5-二氧戊酸合成四吡咯的过程。
Tetrapyrrole biosynthesis from 4,5-dioxovaleric acid in rhodopseudomonas spheroides.
作者信息
Couso R, de Albani M D, Locascio G A, Tigier H A
出版信息
Experientia. 1979 Feb 15;35(2):168-9. doi: 10.1007/BF01920591.
PMID:421821
Abstract
Prophyrin biosynthesis from 4,5-dioxovaleric acid was studied in cell suspensions of R. spheroides. The experiments show that 4,5-dioxovaleric acid is a far precursor of porphyrins through delta amino laevulinic acid formation in a transmination reaction involving also l-alanine. It differs radically from the classical delta aminolaevulinic acid synthesis using glycine and succinyl CoA as substrates.
摘要
在球形红细菌的细胞悬液中研究了由4,5-二氧代戊酸合成卟啉的过程。实验表明，4,5-二氧代戊酸是卟啉的一个远前体，它通过转氨反应生成δ-氨基乙酰丙酸，此反应还涉及L-丙氨酸。它与以甘氨酸和琥珀酰辅酶A为底物的经典δ-氨基乙酰丙酸合成方法截然不同。
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