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[镇静剂对猫大脑皮层兴奋性的影响]

[Effect of tranquilizers on cerebral cortex excitability in cats].

作者信息

Fisenko V P, Machula A I

出版信息

Farmakol Toksikol. 1979 Jan-Feb;42(1):15-9.

PMID:421884
Abstract

Chronic tests on cats showed that diazepam and nitrazepam lower the amplitude of primary responses (PR) of the second somatosensory zone of the brain cortex both to a single and paired stimulation of the thalamo-cortical radiation of fibers. Meprotan, while potentiating the PR to a single stimulation, does not influence the course of the PR restitution cycles. Benacryzine, while enhancing the PR to a single stimulation, produces the appearance of a lengthy phase of depression throughout the PR restitution cycle. In acute tests with unanesthetized, flaxedil immobilized cats, with an isolated cortical band underneath a stimulating electrode, analogous changes in PR both to a single and paired stimulation of the thalamo-cortical radiation of fibers were noted.

摘要

对猫进行的慢性试验表明,地西泮和硝西泮会降低大脑皮层第二体感区对丘脑 - 皮质纤维辐射的单次和配对刺激的初级反应(PR)幅度。美普罗坦在增强对单次刺激的PR时,并不影响PR恢复周期的进程。贝那利嗪在增强对单次刺激的PR时,会在整个PR恢复周期中产生一个漫长的抑制期。在对未麻醉、用三碘季铵酚固定的猫进行的急性试验中,在刺激电极下方有一个孤立的皮质带,观察到对丘脑 - 皮质纤维辐射的单次和配对刺激的PR有类似变化。

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1
[Effect of tranquilizers on cerebral cortex excitability in cats].[镇静剂对猫大脑皮层兴奋性的影响]
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