Rodkina B S, Bolonova L N
Farmakol Toksikol. 1979 Jan-Feb;42(1):81-4.
Experiments on albino rats showed that polyvinylpyridine-N-oxide (PVNO) inhalations (mol. mass 2000; 9.8 +/- 1.2 and 99 +/- 4 mg/m3 for 7 months) slowed down the course of silicosis developing with a gradual entrance and uniform distribution of dust in the lungs, but proved little effective with a one-time introduction of a large amount of "aggressive" dust because of the difficulty for the drug to reach and penetrate the sclerosed sections of the tissue. Considering low toxicity and an insignificant cumulative effect of PVNO, the electivity of its accumulation in the lungs during inhalation and marked protective action of low doses the authors hold it expedient to employ the inhalation method of administering the polymer for prevention of silicosis, while its use for curative purpose is not recommended.
对白化大鼠的实验表明，吸入聚乙烯吡啶-N-氧化物（PVNO）（分子量2000；7个月内浓度为9.8±1.2和99±4毫克/立方米）可减缓矽肺的发展进程，此时粉尘在肺部逐渐进入并均匀分布，但一次性引入大量“侵袭性”粉尘时，该方法效果不佳，因为药物难以到达并穿透组织的硬化部位。考虑到PVNO的低毒性和微不足道的累积效应、其在吸入过程中在肺部积累的选择性以及低剂量时显著的保护作用，作者认为采用聚合物吸入法预防矽肺是适宜的，而不建议将其用于治疗目的。
