美索卡比在大鼠体内的代谢
Metabolism of mesocarb in the rat.
作者信息
Polgár M, Vereczkey L, Szporny L, Czira G, Tamás J, Gács-Baitz E, Holly S
出版信息
Xenobiotica. 1979 Aug;9(8):511-9. doi: 10.3109/00498257909087265.
PMID:42228
Abstract
- Rats treated orally with [14C]mesocarb (I; 3-(1-methyl-2-phenyl[2-(14C]ethyl)-N-(phenylaminocarbonyl)sydnone imine) (50 mg/kg) excrete 35% of the radioactivity in 24 h urine and 51% in 48 h urine. 2. Only traces of unchanged drug were found in urine. Hydroxy-mesocarb (II), dihydroxy-mesocarb (III), amphetamine (VII) and the conjugates of II and III account for 86% of the urinary radioactivity. 3. Cannulated male rats excrete about 40% of the radioactivity in 30 h in bile, mainly as conjugates of II and III.
摘要
- 经口给予[14C]美索卡宾（I；3-(1-甲基-2-苯基[2-(14C]乙基)-N-(苯基氨基甲酰基)环辛二烯亚胺）（50毫克/千克）的大鼠，在24小时尿液中排出35%的放射性，在48小时尿液中排出51%。2. 尿液中仅发现微量未变化的药物。羟基美索卡宾（II）、二羟基美索卡宾（III）、苯丙胺（VII）以及II和III的结合物占尿液放射性的86%。3. 插管的雄性大鼠在30小时内胆汁中排出约40%的放射性，主要以II和III的结合物形式排出。
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