Anderton J M
J Bone Joint Surg Br. 1979 Feb;61(1):82-4. doi: 10.1302/0301-620X.61B1.422640.
Hypophosphatasia in adults is rare. Two elderly sisters presenting with pathological fractures of the femur are reported to illustrate the difficulties in orthopaedic management of this disease. All patients with a history of repeated fractures, especially from minor trauma and with generalised radiological bony abnormality, should be screened for this rare disease. A consistently low level of serum alkaline phosphatase with the presence of phosphoethanolamine in the urine is diagnostic.
成人低磷酸酯酶症较为罕见。本文报道了两名老年姐妹因股骨病理性骨折就诊，以说明该病在骨科治疗中所面临的困难。所有有反复骨折病史的患者，尤其是因轻微创伤导致骨折且伴有全身性骨骼影像学异常者，均应筛查这种罕见疾病。血清碱性磷酸酶持续处于低水平且尿中存在磷酸乙醇胺可作为诊断依据。
