Ogihara T, Hata T, Maruyama A, Mikami H, Nakamaru M, Okada Y, Kumahara Y
J Clin Endocrinol Metab. 1979 Jan;48(1):159-62. doi: 10.1210/jcem-48-1-159.
The renin-angiotensin-aldosterone system in patients with acromegaly was evaluated by infusing [sarcosine1, isoleucine8]angiotensin II, a competitive angiotensin II antagonist, into five acromegalic patients with hypertension and three normotensive acromegalics. The drug was infused at a rate of 600 ng/kg . min for 30 min, 1 h after iv injection of 40 mg furosemide. In addition, before the infusion, plasma samples were obtained for determination of PRA and plasma aldosterone concentration. A significant pressor response to [sarcosine1, isoleucine8]angiotensin II was observed in all eight patients. Preinfusion PRA and plasma aldosterone concentration were significantly lower than in normal controls. It is concluded that in acromegaly, the renin-angiotensin-aldosterone system is suppressed and that this system is probably not involved in maintenance of the high blood pressure observed in some acromegalic patients.
通过向5例患有高血压的肢端肥大症患者和3例血压正常的肢端肥大症患者输注[肌氨酸1，异亮氨酸8]血管紧张素II（一种竞争性血管紧张素II拮抗剂），对肢端肥大症患者的肾素-血管紧张素-醛固酮系统进行了评估。在静脉注射40mg速尿1小时后，以600ng/kg·min的速率输注该药物30分钟。此外，在输注前，采集血浆样本以测定血浆肾素活性（PRA）和血浆醛固酮浓度。在所有8例患者中均观察到对[肌氨酸1，异亮氨酸8]血管紧张素II的显著升压反应。输注前的PRA和血浆醛固酮浓度显著低于正常对照组。得出的结论是，在肢端肥大症中，肾素-血管紧张素-醛固酮系统受到抑制，并且该系统可能不参与某些肢端肥大症患者中所观察到的高血压的维持。
