Ram C V, Holland O B, Fairchild C, Gomez-Sanchez C E
J Clin Pharmacol. 1979 Feb-Mar;19(2-3):148-50. doi: 10.1002/j.1552-4604.1979.tb02472.x.
A withdrawal syndrome consisting of nervousness, palpitations, diaphoresis, and insomnia appeared in three patients within 16--48 hours following discontinuation of guanabenz, a new centrally acting antihypertensive agent. A similar syndrome of sympathetic overactivity has been described with abrupt withdrawal of clonidine. Three of four patients treated with 48 mg/day but none of 20 other patients treated with 32 mg/day or less guanabenz developed this syndrome. None of the three patients developed hypertensive crisis, though one had a modest rise in the blood pressure above baseline levels. It is concluded that guanabenz therapy should not be discontinued abruptly and that, when possible, the dosage should be limited to less than 48 mg/day.
在停用新型中枢性抗高血压药物胍那苄后的16至48小时内，三名患者出现了由紧张、心悸、出汗和失眠组成的戒断综合征。突然停用可乐定后也有类似的交感神经过度活跃综合征的描述。接受48毫克/天治疗的四名患者中有三名出现了这种综合征，但接受32毫克/天或更低剂量胍那苄治疗的其他20名患者中无一出现。这三名患者均未发生高血压危象，尽管有一名患者血压比基线水平有适度升高。结论是，不应突然停用胍那苄治疗，并且在可能的情况下，剂量应限制在每天48毫克以下。
