Nugent S K, Laravuso R, Rogers M C
J Pediatr. 1979 Mar;94(3):481-7. doi: 10.1016/s0022-3476(79)80608-3.
Succinylcholine is a short-acting depolarizing neuromuscular blocker used to facilitate intubation; pancuronium is a longer-acting, nondepolarizing agent commonly employed to control ventilation in pediatric patients. The neuromuscular block produced by both drugs may be modified by patient age, acid-base and electrolyte status, body temperature, and drugs such as aminoglycoside antibiotics; adjustment in dose or in technique of administration may be required. Cardiovascular side-effects, primarily arrhythmias, are occasionally associated with the use of either agent. In contrast to that of succinylcholine, the paralysis from pancuronium is pharmacologically reversible with the combination of atropine and neostigmine.
琥珀酰胆碱是一种短效去极化神经肌肉阻滞剂，用于辅助插管；泮库溴铵是一种长效非去极化剂，常用于控制儿科患者的通气。两种药物产生的神经肌肉阻滞可能会因患者年龄、酸碱和电解质状态、体温以及氨基糖苷类抗生素等药物而改变；可能需要调整剂量或给药技术。心血管副作用，主要是心律失常，偶尔与使用这两种药物中的任何一种有关。与琥珀酰胆碱不同，泮库溴铵引起的麻痹可通过阿托品和新斯的明联合用药在药理学上逆转。
