Identification and synthesis of a methylated catechol metabolite of glutethimide isolated from biological fluids of overdose victims.
作者信息
Andresen B D, Davis F T, Long M D
出版信息
J Pharm Sci. 1979 Mar;68(3):283-8. doi: 10.1002/jps.2600680308.
PMID:423115
Abstract
Urine samples from victims severely intoxicated by glutethimide were hydrolyzed enzymatically. TLC, GLC, and mass spectral analyses revealed a methylated catechol metabolite of the parent drug. Two synthetic pathways are described for the preparation of 2-ethyl-2-(3-methoxy-4-hydroxyphenyl)glutarimide and 2-ethyl-2-(3-hydroxy-4-methoxyphenyl)glutarimde. Comparisons of GLC and mass spectral data to a compound isolated from the body fluids of glutethimide overdose victims conclusively identified a new 3-methoxy-4-hydroxyphenyl metabolite of glutethimide in humans.
摘要
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