4-取代氨基苯甲酸酯季铵盐作为强效解痉剂的合成。
Synthesis of 4-substituted aminobenzoate quaternary salts as potent antispasmodic agents.
作者信息
Ibrahim E S, Soliman R, Gabr M
出版信息
J Pharm Sci. 1979 Mar;68(3):332-5. doi: 10.1002/jps.2600680320.
PMID:423122
Abstract
N-(Diethylaminoethyl)-4-substituted aminobenzoate quaternary salts, N-(diethylaminoethyl)-4-substituted aminobenzamide quaternary salts, 4-substituted acylaminobenzamide quaternary salts, and 4-substituted acylaminosalicylamide derivatives were prepared and tested for antispasmodic activity. Preliminary pharmacological tests on isolated guinea pig ileum revealed that the new compounds possess nonspecific inhibitory action on smooth muscles.
摘要
制备了N-（二乙氨基乙基）-4-取代氨基苯甲酸酯季铵盐、N-（二乙氨基乙基）-4-取代氨基苯甲酰胺季铵盐、4-取代酰氨基苯甲酰胺季铵盐和4-取代酰氨基水杨酰胺衍生物，并对其抗痉挛活性进行了测试。对离体豚鼠回肠的初步药理试验表明，这些新化合物对平滑肌具有非特异性抑制作用。
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