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通过将去蛋白的体液直接进样到高压液相色谱系统中来测定酮洛芬。

Determination of ketoprofen by direct injection of deproteinized body fluids into a high-pressure liquid chromatographic system.

作者信息

Ballerini R, Cambi A, Del Soldato P, Melani F, Meli A

出版信息

J Pharm Sci. 1979 Mar;68(3):366-8. doi: 10.1002/jps.2600680330.

DOI:10.1002/jps.2600680330
PMID:423130
Abstract

A rapid, sensitive, and specific determination of ketoprofen in human and animal deproteinized body fluids by reversed-phase high-pressure liquid chromatography is presented. The acid is detectable in amounts as low as 0.1 microgram/ml. Limits of error are in the range of +/- 5.1% of the sample mean.

摘要

本文介绍了一种通过反相高压液相色谱法快速、灵敏且特异测定人和动物脱蛋白体液中酮洛芬的方法。该酸的检测限低至0.1微克/毫升。误差限度在样品平均值的±5.1%范围内。

相似文献

1
Determination of ketoprofen by direct injection of deproteinized body fluids into a high-pressure liquid chromatographic system.通过将去蛋白的体液直接进样到高压液相色谱系统中来测定酮洛芬。
J Pharm Sci. 1979 Mar;68(3):366-8. doi: 10.1002/jps.2600680330.
2
Determination of ketoprofen in biological fluids by reversed-phase chromatography.采用反相色谱法测定生物流体中的酮洛芬。
J Pharm Sci. 1980 Jul;69(7):763-5. doi: 10.1002/jps.2600690704.
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High-performance liquid chromatographic assay of ketoprofen enantiomers in human plasma and urine.
J Chromatogr. 1987 May 15;416(2):388-93. doi: 10.1016/0378-4347(87)80525-x.
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Highly sensitive determination of ketoprofen in human serum and urine and its application to pharmacokinetic study.人血清和尿液中酮洛芬的高灵敏度测定及其在药代动力学研究中的应用。
J Chromatogr. 1985 Dec 13;345(2):419-24. doi: 10.1016/0378-4347(85)80182-1.
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High-performance liquid chromatographic determination of ketoprofen degradation products.高效液相色谱法测定酮洛芬降解产物
J Chromatogr. 1987 Mar 25;390(2):454-7. doi: 10.1016/s0021-9673(01)94399-7.
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Enantiospecific high-performance liquid chromatographic analysis of 2-phenylpropionic acid, ketoprofen and fenoprofen.2-苯丙酸、酮洛芬和非诺洛芬的对映体特异性高效液相色谱分析
J Chromatogr. 1986 Jan 24;374(2):329-37. doi: 10.1016/s0378-4347(00)83288-0.
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A quantitative selected ion monitoring assay for ketoprofen determination in human biological fluids.一种用于测定人体生物体液中酮洛芬的定量选择离子监测分析方法。
Biomed Mass Spectrom. 1979 Jun;6(6):249-52. doi: 10.1002/bms.1200060605.
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High-performance liquid chromatographic determination of ketoprofen in blood and urine.
J Pharm Sci. 1979 Apr;68(4):484-5. doi: 10.1002/jps.2600680424.
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High-performance liquid chromatographic determination of ketoprofen and naproxen in rat plasma.大鼠血浆中酮洛芬和萘普生的高效液相色谱测定法
J Chromatogr. 1988 Oct 14;431(2):444-9. doi: 10.1016/s0378-4347(00)83116-3.
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Estimation by high-performance liquid chromatography of ketoprofen in plasma. Application to the study of its protein binding.高效液相色谱法测定血浆中酮洛芬。及其在蛋白质结合研究中的应用。
Biomed Pharmacother. 1986;40(3):100-5.

引用本文的文献

1
A high-pressure liquid chromatographic methods for the assay of ketoprofen in plasma and urine, and its application to determining the urinary excretion of free and conjugated ketoprofen following oral administrations of Orudis to man.一种用于测定血浆和尿液中酮洛芬的高压液相色谱法,及其在口服奥鲁地斯后人尿中游离和结合型酮洛芬排泄量测定中的应用。
Br J Clin Pharmacol. 1981 Apr;11(4):395-8. doi: 10.1111/j.1365-2125.1981.tb01142.x.
2
Binding of non-steroid anti-inflammatory drugs and warfarin to liver tissue of rabbits in vitro.非甾体抗炎药与华法林在体外对兔肝组织的结合作用。
Eur J Drug Metab Pharmacokinet. 1987 Jul-Sep;12(3):161-7. doi: 10.1007/BF03189892.