2'-脱氧-5-氟尿苷酸的膦酸酯类似物。
Phosphonate analogue of 2'-deoxy-5-fluorouridylic acid.
作者信息
Montgomery J A, Thomas H J, Kisliuk R L, Gaumont Y
出版信息
J Med Chem. 1979 Jan;22(1):109-11. doi: 10.1021/jm00187a024.
PMID:423172
Abstract
The phosphonate analogue (6) of 2'-deoxy-5-fluorouridylic acid has been prepared via a Pfitzner--Moffatt oxidation and Witting reaction. This compound was found to inhibit thymidylate synthetase from three sources and to be cytotoxic to H.Ep.-2 cells in culture.
摘要
2'-脱氧-5-氟尿苷酸的膦酸酯类似物（6）已通过Pfitzner-Moffatt氧化反应和Witting反应制备而成。发现该化合物可抑制来自三种来源的胸苷酸合成酶，并且对培养中的H.Ep.-2细胞具有细胞毒性。
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