Synthesis and pharmacological properties of [5-isoleucine]-, [8-isoleucine]-, and [5,8-diisoleucine]bradykinin.
作者信息
Chiu A T, Day A R, Radding J A, Freer R J
出版信息
J Med Chem. 1979 Mar;22(3):334-5. doi: 10.1021/jm00189a026.
PMID:423219
Abstract
Three bradykinin analogues have been synthesized in which the phenylalanine residue(s) at positions 5 and/or 8 have been substituted by isoleucine. All these analogues have weak bradykinin-like activity in isolated rat uterine smooth muscle or in rat blood pressure assay. No antagonistic activity was observed with any of these analogues. The importance of phenylalanine at positions 5 and 8 is discussed.
摘要
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