化学物质代谢过程的遗传学方面。

Genetic aspects of metabolic processing of chemical substances.

作者信息

Thorgeirsson S S, Wirth P J

出版信息

J Toxicol Environ Health. 1979 Jan;5(1):83-7. doi: 10.1080/15287397909529727.

Abstract

The Ah locus in the mouse controls the induction of cytochrome P1-450 and at least 10 associated monooxygenase activities. These enzyme systems metabolically potentiate and detoxify chemical carcinogens, environmental pollutants, drugs, and other chemicals, as well as numerous endogenous substrates. With certain substrates cytochrome P1-450 is known to produce a predominance of reactive intermediates and products that differ from those formed by other cytochrome P-450 species. Numerous conditions in the mouse, including cancer, drug toxicity, and birth defects, are directly associated with the Ah locus, which is considered to be a single gene or a small number of genes.

摘要

小鼠中的Ah位点控制细胞色素P1 - 450的诱导以及至少10种相关的单加氧酶活性。这些酶系统在代谢上增强化学致癌物、环境污染物、药物和其他化学物质以及众多内源性底物的活性并使其解毒。已知细胞色素P1 - 450与某些底物反应时会产生大量的反应性中间体和产物，这些中间体和产物与其他细胞色素P - 450种类所形成的不同。小鼠中的许多情况，包括癌症、药物毒性和出生缺陷，都与Ah位点直接相关，Ah位点被认为是一个单基因或少数几个基因。