犬中阿氟烷最低肺泡有效浓度（MAC）的测定。

Determination of the minimum alveolar concentration (MAC) of aliflurane in dogs.

作者信息

Munson E S, Schick L M, Chapin J C, Kushins L G, Navarro A A

出版信息

Anesthesiology. 1979 Dec;51(6):545-7. doi: 10.1097/00000542-197912000-00013.

DOI:10.1097/00000542-197912000-00013

Abstract

The minimum alveolar concentration (MAC) of aliflurane was measured in ten dogs. A value of 1.84 volumes per cent was determined, which correlates well with predictions based on lipid solubility. Induction of anesthesia and recovery were rapid, as would be anticipated with an agent of relatively low solubility in blood (blood-gas partition coefficient = 1.7). Circulatory responses over a relatively narrow range of aliflurane concentrations (0.8 to 1.4 MAC) remained stable, but the development of tachypnea, irregular ventilatory patterns, and increased muscle tone were frequently encountered during aliflurane anesthesis.

摘要

在十只犬中测量了阿氟烷的最低肺泡浓度（MAC）。测定值为1.84体积百分比，这与基于脂溶性的预测结果相关性良好。正如预期的那样，使用在血液中溶解度相对较低的药物（血气分配系数 = 1.7）时，麻醉诱导和苏醒都很快。在相对较窄的阿氟烷浓度范围（0.8至1.4 MAC）内，循环反应保持稳定，但在阿氟烷麻醉期间经常会出现呼吸急促、通气模式不规则和肌张力增加的情况。