大鼠心脏在各种形式心脏肥大时肌肉和胶原部分的生长情况。

The growth of the muscular and collagenous parts of the rat heart in various forms of cardiomegaly.

Bartosová D, Chvapil M, Korecký B, Poupa O, Rakusan K, Turek Z, Vízek M

J Physiol. 1969 Feb;200(2):285-95. doi: 10.1113/jphysiol.1969.sp008693.

Abstract

Cardiomegaly has been produced in rats by sideropenic anaemia, by isoprenaline or thyroxine or by the application of both drugs, by artificial increase in resistance to blood flow and by long-term adaptation to hypoxia and physical stress. The ratio of the growth of muscle to the growth of collagen in the heart has been studied.2. All possible variations in the ratio occurred depending on the type of stimulus used for inducing cardiomegaly and on the dynamics of the development of cardiomegaly. In cardiomegaly induced by sideropenia and by thyroxine the growth of muscle was not accompanied by the growth of collagen. Exposure to hypoxia or isoprenaline administration increased only the growth of collagen in the hypertrophic heart. In all other forms of cardiomegaly muscle and collagen formation were stimulated to the same extent.3. It is concluded that when certain organs hypertrophy during adult life several factors may determine the relative rapidity of growth of the muscular or parenchymal and the collagenous stromal components of the tissue.

摘要

缺铁性贫血、使用异丙肾上腺素或甲状腺素、同时使用这两种药物、人为增加血流阻力以及长期适应缺氧和身体应激等因素均可使大鼠发生心脏肥大。研究了心脏中肌肉生长与胶原蛋白生长的比例。
根据诱导心脏肥大所用刺激的类型以及心脏肥大发展的动态变化，该比例会出现所有可能的变化。在缺铁性贫血和甲状腺素诱导的心脏肥大中，肌肉生长并未伴随胶原蛋白生长。暴露于缺氧环境或给予异丙肾上腺素只会增加肥厚心脏中胶原蛋白的生长。在所有其他形式的心脏肥大中，肌肉和胶原蛋白的形成受到同等程度的刺激。
得出的结论是，在成年期某些器官发生肥大时，多种因素可能决定组织中肌肉或实质成分与胶原性间质成分相对生长的速度。