O'Doherty P J
Lipids. 1979 Jan;14(1):84-7. doi: 10.1007/BF02533574.
The importance of the steric configuration of lysophosphatidylcholine in the lymphatic transport of fat was investigated in bile fistula rats. It was found that the feeding of 1-palmitoyl-sn-glycero-3-phosphocholine increased the lymphatic output of phosphatidyl choline and triacylglycerol, while the feeding of 3-palmitoyl-sn-glycero-1-phosphocholine had no effect. In intestinal microsomes of the bile fistula rats, it was found that the lysophosphatidylcholine acyltransferase was stereospecific in acylating the 1-acyl-sn-glycero-3-phosphocholine enantiomer. The significance of these findings is briefly discussed.
在胆瘘大鼠中研究了溶血磷脂酰胆碱的空间构型在脂肪淋巴转运中的重要性。发现喂食1-棕榈酰-sn-甘油-3-磷酸胆碱可增加磷脂酰胆碱和三酰甘油的淋巴输出，而喂食3-棕榈酰-sn-甘油-1-磷酸胆碱则没有效果。在胆瘘大鼠的肠微粒体中，发现溶血磷脂酰胆碱酰基转移酶在酰化1-酰基-sn-甘油-3-磷酸胆碱对映体时具有立体特异性。简要讨论了这些发现的意义。
