Ward F P, Swaim S F, Ohanesian N, McLaughlin H J
Can J Comp Med. 1969 Jan;33(1):20-4.
In this report, the effects of hyaluronidase on the absorption of intramuscular succinylcholine chloride in goats are discussed. Twenty-five mature, mixed-strain dairy goats were immobilized with 0.33 mg/kg of the drug. An additional 25 goats were given corresponding doses to which hyaluronidase (150 NF units per vial of succinylcholine) had been added. The latent period (the time from injection to collapse) is reduced by 25% in goats given the drug-enzyme mixture. It is concluded that hyaluronidase increases the rate of absorption of succinylcholine chloride. However, it produces no significant difference in the duration of paralysis.
在本报告中，讨论了透明质酸酶对山羊肌肉注射氯化琥珀胆碱吸收的影响。二十五只成熟的混种奶山羊用0.33毫克/千克的该药物进行麻醉。另外二十五只山羊给予添加了透明质酸酶（每瓶琥珀胆碱含150美国药典单位）的相应剂量。给予药物 - 酶混合物的山羊的潜伏期（从注射到瘫倒的时间）缩短了25%。得出的结论是，透明质酸酶提高了氯化琥珀胆碱的吸收速率。然而，它在麻痹持续时间上没有产生显著差异。
