哇巴因、钠和钾离子以及温度对兔红细胞中铁积累的影响
Accumulation of iron in the rabbit erythroid cell as affected by ouabain, sodium and potassium ions, and temperature.
作者信息
Wise W C, Archdeacon J W
出版信息
J Gen Physiol. 1969 Apr;53(4):487-97. doi: 10.1085/jgp.53.4.487.
Abstract
Reticulocytosis was induced in rabbits with phenylhydrazine. The accumulation of a small part of (59)Fe in blood cells of these animals was inhibited by ouabain and related to changes in extracellular sodium and potassium concentrations. Sodium increases movement from the cell surface into the cell, whereas potassium and ouabain decrease this movement. (59)Fe movement was found to be temperature-dependent. Thus, the Na-K ATPase system appears to be important in the movement of iron from the cell membrane (stroma) to the cell interior, but influences only a small part of the total iron transport.
摘要
用苯肼诱导家兔发生网织红细胞增多。哇巴因抑制了这些动物血细胞中一小部分（59）铁的积累，且这种积累与细胞外钠和钾浓度的变化有关。钠增加了从细胞表面进入细胞的移动，而钾和哇巴因则减少这种移动。发现（59）铁的移动与温度有关。因此，钠钾ATP酶系统似乎在铁从细胞膜（基质）向细胞内部的移动中起重要作用，但仅影响总铁转运的一小部分。
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Accumulation of iron in the rabbit erythroid cell as affected by ouabain, sodium and potassium ions, and temperature.哇巴因、钠和钾离子以及温度对兔红细胞中铁积累的影响
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