Matsumura F, Patil K C
Science. 1969 Oct 3;166(3901):121-2. doi: 10.1126/science.166.3901.121.
The insecticide DDT selectively inhibits the action of a Na(+), K(+), Mg(2+)-adenosine triphosphatase found in the nerve ending fraction of the rat brain. As judged by the concentrations of inhibitors that give 50 percent of enzyme inhibition, DDT was approximately 1000 times more toxic than its non-insecticidal analog, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene. The degrees of inhibition of this enzyme system by various toxic and nontoxic DDT analogs were closely related to a general toxicity in vivo of these compounds. Moreover, the extents of inhibition of this enzyme system by DDT were much higher at low temperatures, an indication of a causal relation between poisoning in vivo by DDT and the inhibition in vitro of the Na(+), K(+), Mg(2+)-adenosine triphosphatase system.
杀虫剂滴滴涕（DDT）可选择性抑制大鼠脑内神经末梢部分中发现的一种钠、钾、镁-三磷酸腺苷酶的活性。根据产生50%酶抑制率的抑制剂浓度判断，滴滴涕的毒性约为其非杀虫类似物1,1-二氯-2,2-双（对氯苯基）乙烯的1000倍。各种有毒和无毒滴滴涕类似物对该酶系统的抑制程度与这些化合物在体内的一般毒性密切相关。此外，在低温下滴滴涕对该酶系统的抑制程度要高得多，这表明滴滴涕在体内中毒与体外抑制钠、钾、镁-三磷酸腺苷酶系统之间存在因果关系。
