坏血病对豚鼠愈合伤口中含己糖胺物质的影响。
The effect of scurvy on hexosamine-containing substances in healing wounds in guinea pigs.
作者信息
Bates C J, Levene C I, Kodicek E
出版信息
Biochem J. 1969 Aug;113(5):783-90. doi: 10.1042/bj1130783.
Abstract
- Granulation tissue from healing tendonectomy wounds in guinea pigs was analysed and the effects of inanition and ascorbic acid deficiency on this tissue were investigated. 2. Inanition produced no significant effect on either the glucosamine or the galactosamine content of the tissue. Ascorbic acid deficiency decreased the galactosamine content without affecting the glucosamine content. 3. Fractionation of papain-digested granulation tissue gave three major fractions, which behaved respectively as glycopeptide, hyaluronic acid and a sulphated glycosaminoglycan mixture. At least half of the sulphated glycosaminoglycan mixture behaved as dermatan sulphate. 4. Inanition produced no consistent effect on the fractions examined. In ascorbic acid deficiency, a decrease in the sulphated glycosaminoglycan fraction was observed, which accounted for the decreased galactosamine content of the tissue. This was accompanied by a decrease in hyaluronic acid and a slight increase in the glycopeptide fraction.
摘要
- 对豚鼠愈合的腱切除伤口处的肉芽组织进行了分析，并研究了饥饿和抗坏血酸缺乏对该组织的影响。2. 饥饿对组织中的氨基葡萄糖或半乳糖胺含量均无显著影响。抗坏血酸缺乏会降低半乳糖胺含量，而不影响氨基葡萄糖含量。3. 木瓜蛋白酶消化的肉芽组织分级分离得到三个主要级分，它们分别表现为糖肽、透明质酸和硫酸化糖胺聚糖混合物。硫酸化糖胺聚糖混合物中至少一半表现为硫酸皮肤素。4. 饥饿对所检测的级分没有一致的影响。在抗坏血酸缺乏的情况下，观察到硫酸化糖胺聚糖级分减少，这解释了组织中半乳糖胺含量的降低。同时伴随着透明质酸减少和糖肽级分略有增加。
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引用本文的文献
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本文引用的文献
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