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精神药物对醛缩酶、线粒体苹果酸脱氢酶和Mg++Na+K+三磷酸腺苷酶的影响。

The influence of psychotropic drugs on aldole, mitochondrial malic dehydrogenase and Mg++na+K+ adenosine triphosphatase.

作者信息

Chowdhury A K, Rogers H, Skinner A, Spector R G, Watts D C

出版信息

Br J Pharmacol. 1969 Oct;37(2):459-67. doi: 10.1111/j.1476-5381.1969.tb10582.x.

DOI:10.1111/j.1476-5381.1969.tb10582.x
PMID:4242360
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1703713/
Abstract
  1. The experiment investigated the effects of psychotropic drugs on enzymes in vitro.2. Chlorpromazine inhibits mitochondrial malate dehydrogenase in concentrations of 1.4x10(-4)M and above. No effect was observed below this concentration.3. A sharp inflection in the [unk]/drug plot was also seen with chlorpromazine (1.4 x 10(-4)M), trifluoperazine (1 x 10(-5)M), prochlorperazine (1 x 10(-4)M), and amylobarbitone (8 x 10(-3)M) acting on rat brain (Na(+)-K(+)-) Mg(++)-ATPase and with chlorpromazine (10(-4)M) and imipramine (3 x 10(-4)M) acting on aldolase.
摘要

  1. 该实验在体外研究了精神药物对酶的影响。

  2. 氯丙嗪在浓度为1.4×10⁻⁴M及以上时抑制线粒体苹果酸脱氢酶。低于此浓度未观察到影响。

  3. 氯丙嗪（1.4×10⁻⁴M）、三氟拉嗪（1×10⁻⁵M）、丙氯拉嗪（1×10⁻⁴M）和戊巴比妥（8×10⁻³M）作用于大鼠脑（钠钾）镁 -ATP酶，以及氯丙嗪（10⁻⁴M）和丙咪嗪（3×10⁻⁴M）作用于醛缩酶时，在[未知]/药物曲线上也出现了明显的拐点。

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1
The influence of psychotropic drugs on aldole, mitochondrial malic dehydrogenase and Mg++na+K+ adenosine triphosphatase.精神药物对醛缩酶、线粒体苹果酸脱氢酶和Mg++Na+K+三磷酸腺苷酶的影响。
Br J Pharmacol. 1969 Oct;37(2):459-67. doi: 10.1111/j.1476-5381.1969.tb10582.x.
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Inhibition of Na+K+-activated adenosine triphosphatase activity in rat brain by substituted phenothiazines.取代吩噻嗪对大鼠脑内钠钾激活的三磷酸腺苷酶活性的抑制作用。
Biochem Pharmacol. 1966 Jun;15(6):703-10. doi: 10.1016/0006-2952(66)90004-9.
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Comparative study on the inhibition of Na + , K + -activated ATPase activity by chlorpromazine, promazine, imipramine, and their monodesmethyl metabolites.
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Biochem Biophys Res Commun. 1974 May 7;58(1):263-7. doi: 10.1016/0006-291x(74)90921-8.

引用本文的文献

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Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives.吩噻嗪衍生物对细菌核糖核酸酶P RNA的抑制作用。
Biomolecules. 2016 Sep 8;6(3):38. doi: 10.3390/biom6030038.
2
Evidence for interaction between chlorpromazine and aldolase.氯丙嗪与醛缩酶之间相互作用的证据。
Br J Pharmacol. 1970 May;39(1):248P-249P.
3
Further effects of chlorpromazine on the hexose permeability of the human erythrocyte.氯丙嗪对人红细胞己糖通透性的进一步影响。
J Physiol. 1973 Aug;232(3):597-608. doi: 10.1113/jphysiol.1973.sp010287.

本文引用的文献

1
Effects of chlorpromazine on biological membranes--I. Chlorpromazine-induced changes in liver mitochondria.
Biochem Pharmacol. 1963 Jan;12:37-46. doi: 10.1016/0006-2952(63)90007-8.
2
Carbohydrate metabolism in citric acid fermentation. 4. Purification and properties of aldolase from Aspergillus niger.柠檬酸发酵中的碳水化合物代谢。4. 黑曲霉醛缩酶的纯化及性质
Biochem J. 1956 May;63(1):94-105. doi: 10.1042/bj0630094.
3
Suppression of enzyme release from isolated rat liver lysosomes by non-steroidal anti-inflammatory drugs.非甾体抗炎药对离体大鼠肝溶酶体酶释放的抑制作用。
Biochem Pharmacol. 1968 Oct;17(10):2023-32. doi: 10.1016/0006-2952(68)90175-5.
4
Protein conformations in cellular membranes.细胞膜中的蛋白质构象
Proc Natl Acad Sci U S A. 1966 Nov;56(5):1552-9. doi: 10.1073/pnas.56.5.1552.