精神药物对醛缩酶、线粒体苹果酸脱氢酶和Mg++Na+K+三磷酸腺苷酶的影响。
The influence of psychotropic drugs on aldole, mitochondrial malic dehydrogenase and Mg++na+K+ adenosine triphosphatase.
作者信息
Chowdhury A K, Rogers H, Skinner A, Spector R G, Watts D C
出版信息
Br J Pharmacol. 1969 Oct;37(2):459-67. doi: 10.1111/j.1476-5381.1969.tb10582.x.
Abstract
- The experiment investigated the effects of psychotropic drugs on enzymes in vitro.2. Chlorpromazine inhibits mitochondrial malate dehydrogenase in concentrations of 1.4x10(-4)M and above. No effect was observed below this concentration.3. A sharp inflection in the [unk]/drug plot was also seen with chlorpromazine (1.4 x 10(-4)M), trifluoperazine (1 x 10(-5)M), prochlorperazine (1 x 10(-4)M), and amylobarbitone (8 x 10(-3)M) acting on rat brain (Na(+)-K(+)-) Mg(++)-ATPase and with chlorpromazine (10(-4)M) and imipramine (3 x 10(-4)M) acting on aldolase.
摘要
该实验在体外研究了精神药物对酶的影响。
氯丙嗪在浓度为1.4×10⁻⁴M及以上时抑制线粒体苹果酸脱氢酶。低于此浓度未观察到影响。
氯丙嗪（1.4×10⁻⁴M）、三氟拉嗪（1×10⁻⁵M）、丙氯拉嗪（1×10⁻⁴M）和戊巴比妥（8×10⁻³M）作用于大鼠脑（钠钾）镁 -ATP酶，以及氯丙嗪（10⁻⁴M）和丙咪嗪（3×10⁻⁴M）作用于醛缩酶时，在[未知]/药物曲线上也出现了明显的拐点。
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