牛乳中多形核白细胞的吞噬作用及相关现象
Phagocytosis and related phenomena in polymorphonuclear leukocytes from cow's milk.
作者信息
Kent G M, Newbould F H
出版信息
Can J Comp Med. 1969 Jul;33(3):214-9.
There were fewer efficient phagocytes among leukocytes collected from artificially irritated mammary glands than among the leukocytes from blood of the same animals. The milk polymorphonuclear (PMN) leukocytes adhered poorly to a column of siliconised glass beads when compared with the blood cells. However, investigations of the O(2) uptake and CO(2) production of the milk PMN leukocytes revealed that these cells appeared to utilize metabolic pathways similar to those used by human and guinea pig PMN leukocytes during phagocytosis. These pathways are associated with degranulation and the production of H(2)O(2) following particle ingestion. It is therefore suggested that the milk PMN leukocytes appear not to have lost the ability to produce this bactericidal substance.
从人工刺激的乳腺中收集的白细胞中，有效吞噬细胞的数量比同一动物血液中的白细胞少。与血细胞相比，乳汁中的多形核（PMN）白细胞与硅化玻璃珠柱的粘附性较差。然而，对乳汁PMN白细胞的氧气摄取和二氧化碳产生的研究表明，这些细胞在吞噬过程中似乎利用了与人类和豚鼠PMN白细胞相似的代谢途径。这些途径与脱颗粒以及颗粒摄取后过氧化氢的产生有关。因此，有人认为乳汁PMN白细胞似乎并未丧失产生这种杀菌物质的能力。
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