Gross S R, Aronow L, Pratt W B
J Cell Biol. 1970 Jan;44(1):103-14. doi: 10.1083/jcb.44.1.103.
It has been determined that cortisol and a few other steroids are transported outward from certain mammalian cells growing in vitro. The extrusion process is temperature dependent, glucose dependent, saturable, and operates for only a few selected steroids. Many, but not all, steroids are able to block the extrusion process but are not themselves transported. The outward transport process for steroids has been found in mouse fibroblasts, mouse lymphoma cells, and functional mouse adrenal gland tumor cells growing in vitro. The transport process is not present in two varieties of cells cultured from human sources-HeLa or diploid fibroblasts, WI-38.
已确定皮质醇和其他一些类固醇会从体外生长的某些哺乳动物细胞向外转运。这种外排过程依赖于温度、葡萄糖，具有饱和性，并且只对少数几种选定的类固醇起作用。许多（但不是所有）类固醇能够阻断外排过程，但它们自身并不被转运。类固醇的向外转运过程已在体外生长的小鼠成纤维细胞、小鼠淋巴瘤细胞和功能性小鼠肾上腺肿瘤细胞中发现。在源自人类的两种细胞——HeLa细胞或二倍体成纤维细胞WI - 38中不存在这种转运过程。
