体外培养的哺乳动物细胞对皮质醇的外向转运。
The outward transport of cortisol by mammalian cells in vitro.
作者信息
Gross S R, Aronow L, Pratt W B
出版信息
J Cell Biol. 1970 Jan;44(1):103-14. doi: 10.1083/jcb.44.1.103.
Abstract
It has been determined that cortisol and a few other steroids are transported outward from certain mammalian cells growing in vitro. The extrusion process is temperature dependent, glucose dependent, saturable, and operates for only a few selected steroids. Many, but not all, steroids are able to block the extrusion process but are not themselves transported. The outward transport process for steroids has been found in mouse fibroblasts, mouse lymphoma cells, and functional mouse adrenal gland tumor cells growing in vitro. The transport process is not present in two varieties of cells cultured from human sources-HeLa or diploid fibroblasts, WI-38.
摘要
已确定皮质醇和其他一些类固醇会从体外生长的某些哺乳动物细胞向外转运。这种外排过程依赖于温度、葡萄糖，具有饱和性，并且只对少数几种选定的类固醇起作用。许多（但不是所有）类固醇能够阻断外排过程，但它们自身并不被转运。类固醇的向外转运过程已在体外生长的小鼠成纤维细胞、小鼠淋巴瘤细胞和功能性小鼠肾上腺肿瘤细胞中发现。在源自人类的两种细胞——HeLa细胞或二倍体成纤维细胞WI - 38中不存在这种转运过程。
相似文献
1
The outward transport of cortisol by mammalian cells in vitro.体外培养的哺乳动物细胞对皮质醇的外向转运。
J Cell Biol. 1970 Jan;44(1):103-14. doi: 10.1083/jcb.44.1.103.
2
The active transport of cortisol by mouse fibroblasts growing in vitro.体外培养的小鼠成纤维细胞对皮质醇的主动转运。
Proc West Pharmacol Soc. 1969;12:54-8.
3
The active transport of cortisol by mouse fibroblasts growing in vitro.体外培养的小鼠成纤维细胞对皮质醇的主动转运。
Biochem Biophys Res Commun. 1968 Jul 11;32(1):66-72. doi: 10.1016/0006-291x(68)90427-0.
4
Specific glucocorticoid-binding macromolecules from mouse fibroblasts growing in vitro. A possible steroid receptor for growth inhibition.
Mol Pharmacol. 1970 Sep;6(5):500-12.
5
Adaptation of mammalian cells to cold respiration and KCN sensitivity of cold-adapted cells.哺乳动物细胞对冷呼吸的适应以及冷适应细胞的氰化钾敏感性。
Physiol Bohemoslov. 1969;18(3):295-301.
6
[Effect of various detachment procedures on the permeability and metabolism of permanent tissue culture cells].
Z Gesamte Exp Med Einschl Exp Chir. 1970;153(1):51-8.
7
Computational analysis of liquid chromatography-tandem mass spectrometric steroid profiling in NCI H295R cells following angiotensin II, forskolin and abiraterone treatment.血管紧张素II、福斯高林和阿比特龙处理后NCI H295R细胞中液相色谱-串联质谱类固醇分析的计算分析
J Steroid Biochem Mol Biol. 2016 Jan;155(Pt A):67-75. doi: 10.1016/j.jsbmb.2015.09.038. Epub 2015 Oct 3.
8
Uptake of 2,6-diaminopurine-2-14C by 2,6-diaminopurine-sensitive and -resistant L strain mouse cells grown on plastic discs.
Can J Physiol Pharmacol. 1970 Nov;48(11):791-800. doi: 10.1139/y70-114.
9
10
On the differential cytotoxicity of actinomycin D.论放线菌素D的差异细胞毒性。
J Cell Biol. 1971 Sep;50(3):746-61. doi: 10.1083/jcb.50.3.746.
引用本文的文献
1
An acetylation/deacetylation cycle controls the export of sterols and steroids from S. cerevisiae.乙酰化/去乙酰化循环控制着酿酒酵母中固醇和类固醇的输出。
EMBO J. 2007 Dec 12;26(24):5109-19. doi: 10.1038/sj.emboj.7601924. Epub 2007 Nov 22.
2
Cortisol is transported by the multidrug resistance gene product P-glycoprotein.皮质醇由多药耐药基因产物P-糖蛋白转运。
Br J Cancer. 1993 Feb;67(2):284-9. doi: 10.1038/bjc.1993.54.
3
LEM1, an ATP-binding-cassette transporter, selectively modulates the biological potency of steroid hormones.LEM1是一种ATP结合盒转运蛋白，可选择性调节类固醇激素的生物活性。
Proc Natl Acad Sci U S A. 1995 May 9;92(10):4701-5. doi: 10.1073/pnas.92.10.4701.
4
Biphasic entry of glucocorticoids into cultured human skin keratinocytes and fibroblasts.
Arch Dermatol Res. 1983;275(5):334-44. doi: 10.1007/BF00417208.
5
Receptor-mediated pharmacodynamics of prednisolone in the rat.大鼠体内泼尼松龙的受体介导药效学
J Pharmacokinet Biopharm. 1986 Oct;14(5):469-93. doi: 10.1007/BF01059656.
本文引用的文献
1
Carbohydrate and amino acid transport by mammalian cells grown in tissue culture.组织培养中生长的哺乳动物细胞对碳水化合物和氨基酸的转运
Exp Cell Res. 1962 Jun;27:31-47. doi: 10.1016/0014-4827(62)90041-1.
2
Glutamine metabolism by animal cells growing in a synthetic medium.在合成培养基中生长的动物细胞的谷氨酰胺代谢。
Exp Cell Res. 1962 Aug;27:307-16. doi: 10.1016/0014-4827(62)90233-1.
3
Metabolic reactions of cells in tissue culture. I. Polarographic measurements of endogenous respiration of cells cultured in vitro.组织培养中细胞的代谢反应。I. 体外培养细胞内源性呼吸的极谱测量。
Biochim Biophys Acta. 1959 Oct;35:354-7. doi: 10.1016/0006-3002(59)90384-1.
4
5
Studies on the binding of cortisol-4-14C by human leucocytes in vitro.人白细胞体外结合皮质醇-4-¹⁴C的研究。
Acta Endocrinol (Copenh). 1963 Jan;42:12-20. doi: 10.1530/acta.0.0420012.
6
Glucuronide formation in the transport of estradiol by rat intestine in vitro.
Biochim Biophys Acta. 1963 Jan 1;69:68-73. doi: 10.1016/0006-3002(63)91226-5.
7
Hormone-producing cultures of adrenal and pituitary tumor origin.源自肾上腺和垂体肿瘤的激素分泌培养物。
Proc Natl Acad Sci U S A. 1962 Jul 15;48(7):1184-90. doi: 10.1073/pnas.48.7.1184.
8
Reactive sites and biological transport.反应位点与生物转运
Adv Protein Chem. 1960;15:239-314. doi: 10.1016/s0065-3233(08)60310-1.
9
10
Measurement of cell growth in tissue culture with a phenol reagent (folin-ciocalteau).用酚试剂（福林-西奥卡泰奥试剂）测量组织培养中的细胞生长
Proc Soc Exp Biol Med. 1956 Feb;91(2):305-7. doi: 10.3181/00379727-91-22245.
Zotero 插件