铁在管腔内从胃运输至小肠黏膜。
Intraluminal transport of iron from stomach to small-intestinal mucosa.
作者信息
Jacobs A, Miles P M
出版信息
Br Med J. 1969 Dec 27;4(5686):778-81. doi: 10.1136/bmj.4.5686.778.
Abstract
Inorganic iron rarely exceeds 10(-4) molar concentration in the stomach after a meal. Natural sugars, ascorbic acid, citric acid, and amino-acids form iron complexes, and if they are present in the meal complexing occurs when the gastric contents are neutralized. In their absence an iron complex is formed with gastric mucopolysaccharide, which acts as a carrier, stable at neutral pH. Iron can be detached from this carrier at neutral pH by some low molecular weight substances, of which citric acid, ascorbic acid, and cysteine are particularly effective at low concentrations. Under normal circumstances most of the iron released from food in the stomach becomes bound to the mucopolysaccharide carrier.
摘要
饭后胃中无机铁的浓度很少超过10⁻⁴摩尔浓度。天然糖、抗坏血酸、柠檬酸和氨基酸会形成铁络合物，如果它们存在于食物中，当胃内容物中和时就会发生络合。如果没有这些物质，铁会与胃粘多糖形成络合物，胃粘多糖作为载体，在中性pH值下稳定。在中性pH值下，一些低分子量物质可以使铁从该载体上分离，其中柠檬酸、抗坏血酸和半胱氨酸在低浓度时特别有效。在正常情况下，胃中从食物释放的大部分铁会与粘多糖载体结合。
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2
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3
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Surg Forum. 1965;16:319-21.
4
The iron-binding properties of gastric juice.胃液的铁结合特性。
Clin Chim Acta. 1969 Apr;24(1):87-92. doi: 10.1016/0009-8981(69)90144-2.
5
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