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糖尿病发病初期及正常体重人群的血脂水平

[Blood lipid level in the initial stages of diabetes mellitus and normal body mass].

作者信息

Zaripova Z Kh

出版信息

Probl Endokrinol (Mosk). 1979 Mar-Apr;25(2):11-5.

PMID:424383
Abstract

The authors studied the blood level of tryglycerides, cholesterol, and free fatty acids (FFA) during glucose tolerance test (GTT) in 30 women with doubtful, and in 36--with diabetic GIT. There proved to be a significant elevation of the FFA level in the blood serum of persons with a doubtful GTT type and a significant elevation of the FFA, triglycerides, and cholesterol levels in persons with diabetic GGT. The FFA levels reduction curve following glucose load in persons with a doubtful and diabetic GTT proved to be more delayed. Disturbances of lipid metabolism and reduction of adipose tissue insulin sensitivity occured as soon as the early stages of diabetes mellitus. This pointed to the necessity of diabetes mellitus treatment at its early stages for the normalization of metabolic disturbances. Determination of blood lipids level can aid detection of early diabetes mellitus.

摘要

作者研究了30名糖耐量可疑的女性和36名患有糖尿病性糖耐量异常的女性在葡萄糖耐量试验(GTT)期间甘油三酯、胆固醇和游离脂肪酸(FFA)的血液水平。结果发现,糖耐量可疑类型的人的血清中FFA水平显著升高,而患有糖尿病性糖耐量异常的人的FFA、甘油三酯和胆固醇水平显著升高。糖耐量可疑和糖尿病性糖耐量异常的人在葡萄糖负荷后FFA水平降低曲线被证明更延迟。在糖尿病早期就出现了脂质代谢紊乱和脂肪组织胰岛素敏感性降低。这表明有必要在糖尿病早期进行治疗以使代谢紊乱正常化。测定血脂水平有助于早期糖尿病的检测。

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