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阿霉素诱导的皮肤及皮下损伤的组织病理学发病机制。

Histopathogenesis of skin and subcutaneous injury induced by adriamycin.

作者信息

Luedke D W, Kennedy P S, Rietschel R L

出版信息

Plast Reconstr Surg. 1979 Apr;63(4):463-5. doi: 10.1097/00006534-197904000-00003.

DOI:10.1097/00006534-197904000-00003
PMID:424456
Abstract

Extravasation of Adriamycin from an intravenous needle or catheter can produce a progressive skin necrosis and deep painful ulceration. The pathological changes which result in this ulceration were studied in a rabbit model. The earliest changes include vascular obliteration and necrobiosis of collagen. At no point were inflammatory cells found to play a primary role.

摘要

阿霉素从静脉注射针或导管外渗可导致进行性皮肤坏死和深部疼痛性溃疡。在兔模型中研究了导致这种溃疡的病理变化。最早的变化包括血管闭塞和胶原坏死。在任何时候都未发现炎症细胞起主要作用。

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Histopathogenesis of skin and subcutaneous injury induced by adriamycin.阿霉素诱导的皮肤及皮下损伤的组织病理学发病机制。
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