关于小鼠皮肤肿瘤发生的生化机制。II. 起始剂量的二甲基苯蒽（DMBA）和促癌剂量的佛波醇-12,13-二酯（TPA）对核酸生物合成的早期影响。 - Suppr

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On the biochemical mechanism of tumorigenesis in mouse skin. II. Early effects on the biosynthesis of nucleic acids induced by initiating doses of DMBA and by promoting doses of phorbol-12.13-diester TPA.

作者信息

Paul D, Hecker E

出版信息

Z Krebsforsch. 1969;73(2):149-63.

PMID:4245380

Abstract

摘要

相似文献

On the biochemical mechanism of tumorigenesis in mouse skin. II. Early effects on the biosynthesis of nucleic acids induced by initiating doses of DMBA and by promoting doses of phorbol-12.13-diester TPA.关于小鼠皮肤肿瘤发生的生化机制。II. 起始剂量的二甲基苯蒽（DMBA）和促癌剂量的佛波醇-12,13-二酯（TPA）对核酸生物合成的早期影响。

Z Krebsforsch. 1969;73(2):149-63.

Stimulation of DNA synthesis in the mouse epidermis at the stage of initiation of carcinogenesis.在致癌作用起始阶段对小鼠表皮中DNA合成的刺激。

Bull Exp Biol Med. 1974 Oct;77(4):434-6. doi: 10.1007/BF00798108.

Effects of carcinogenic, noncarcinogenic, and cocarcinogenic agents on the biosynthesis of nucleic acids in mouse skin.致癌剂、非致癌剂和促癌剂对小鼠皮肤核酸生物合成的影响。

Cancer Res. 1969 Jun;29(6):1218-25.

Macromolecular synthesis following a single application of polycyclic hydrocarbons used as initiators of mouse skin tumorigenesis.单次应用用作小鼠皮肤肿瘤发生引发剂的多环烃后大分子的合成。

Cancer Res. 1974 Apr;34(4):771-7.

Fast onset of DNA synthesis stimulated by tumor promotor in mouse epidermis at the initation stage of carcinogenesis.

J Natl Cancer Inst. 1973 Dec;51(6):1861-4. doi: 10.1093/jnci/51.6.1861.

Early effects of 12-O-tetradecanoyl-phorbol-13-acetate on the incorporation of tritiated precursor into DNA and the thickness of the interfollicular epidermis, and their relation to tumor promotion in mouse skin.12-O-十四烷酰佛波醇-13-乙酸酯对氚标记前体掺入DNA及毛囊间表皮厚度的早期影响及其与小鼠皮肤肿瘤促进作用的关系。

Cancer Res. 1972 Jul;32(7):1562-8.

The localization of phorbol ester 14C acetate in papillomas that were initiated with 7,12 DMBA and promoted with phorbol ester. An electron microscopic autoradiography study.

J Invest Dermatol. 1971 Feb;56(2):140-6. doi: 10.1111/1523-1747.ep12260717.

Macromolecular synthesis following a single application of alkylating agents used as initiators of mouse skin tumorigenesis.单次应用用作小鼠皮肤肿瘤发生引发剂的烷化剂后的大分子合成。

Cancer Res. 1973 Apr;33(4):769-76.

Effect of tumor promoters on cell kinetics in mouse epidermis.肿瘤启动子对小鼠表皮细胞动力学的影响。

J Natl Cancer Inst. 1972 Jul;49(1):131-7.

The effect of croton oil pretreatment on skin tumor initiation in mice.巴豆油预处理对小鼠皮肤肿瘤起始的影响。

Cancer Res. 1969 Oct;29(10):1773-80.

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Phorbol ester stimulates choline incorporation.佛波酯刺激胆碱掺入。

Naturwissenschaften. 1971 Jun;58(6):323. doi: 10.1007/BF00624744.

Cocarcinogenic croton oil factor A1 stimulates lipid synthesis in cell cultures.促癌巴豆油因子A1刺激细胞培养物中的脂质合成。

Experientia. 1971 Jan 15;27(1):46-7. doi: 10.1007/BF02137733.

[Action mechanism of vitamin A acid (tretinoin)].

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Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1971;76(2):113-23. doi: 10.1007/BF00284422.

Biochemical mechanism of tumorigenesis in mouse skin. 3. Decrease in tumor yields by poly I-C administered during initiation of skin b y and intragastric dose of 7,12-dimethyl-benz(a)anthracene.小鼠皮肤肿瘤发生的生化机制。3. 在经胃内给予7,12-二甲基苯并(a)蒽启动皮肤肿瘤形成过程中，通过给予聚肌胞苷酸降低肿瘤发生率。

Z Krebsforsch. 1970;74(4):383-9.

Induction of the deficient acid DNAse activity in mouse interfollicular epidermis by croton oil as a possible tumor promoting mechanism.巴豆油诱导小鼠毛囊间表皮中酸性DNA酶活性缺乏作为一种可能的肿瘤促进机制。

Z Krebsforsch Klin Onkol Cancer Res Clin Oncol. 1977 Nov 18;90(2):197-210. doi: 10.1007/BF00285326.

本文引用的文献

A new, quantitative, approach to the study of the stages of chemical cartinogenesis in the mouse's skin.一种研究小鼠皮肤化学致癌作用阶段的新的定量方法。

Br J Cancer. 1947 Dec;1(4):383-91. doi: 10.1038/bjc.1947.36.

[Autoradiographic studies on malignant degeneration of the epidermal cells of the skin of mice after application of methylcholanthrene].

Beitr Pathol Anat. 1961 Dec;125:280-303.

[The mechanism and temporal course of physiological regeneration in multilayer pavement epithelium and in the mucosa of the gastrointestinal tract of the white mouse. (Autoradiographic studies with H3-labelled-thymidine)].[小白鼠多层扁平上皮及胃肠道黏膜生理再生的机制与时间进程。（用H3标记胸腺嘧啶核苷的放射自显影研究）]

Beitr Pathol Anat. 1961 Dec;125:374-402.

THE RELATIONSHIP OF THE CELL CYCLE TO TUMOR GROWTH AND CONTROL OF CELL DIVISION: A REVIEW.细胞周期与肿瘤生长及细胞分裂控制的关系：综述

Cancer Res. 1965 Jun;25:581-95.

[ON THE ACTIVE AGENT OF CROTON OIL. 3. PURE DEMONSTRATION AND CHARACTERIZATION OF A TOXIC, INFLAMMATORY AND COCARCINOGENIC HIGHLY ACTIVE SUBSTANCE].

Z Naturforsch B. 1965 Mar;20:216-26.

[COMPARATIVE AUTORADIOGRAPHIC STUDIES ON THE EFFECT OF CARCINOGENS, CIGARETTE SMOKE CONDENSATE AND SOLVENTS ON THE MOUSE SKIN].

Z Krebsforsch. 1965 Feb 3;66:466-72.

EXPERIMENTAL EPIDERMAL HYPERPLASIA IN MICE: RELATION TO CARCINOGENESIS.小鼠实验性表皮增生：与致癌作用的关系。

Acta Pathol Microbiol Scand Suppl (1926). 1964:SUPPL 169:1+.

INHIBITION BY A CARCINOGENIC HYDROCARBON OF INCORPORATION OF TRITIATED CYTIDINE INTO MOUSE EPIDERMAL CELLS.一种致癌碳氢化合物对氚标记胞苷掺入小鼠表皮细胞的抑制作用。

Nature. 1964 Aug 1;203:521-3. doi: 10.1038/203521a0.

DIURNAL VARIATION IN THE SUSCEPTIBILTY OF MOUSE EPIDERMIS TO CARCINOGEN AND ITS RELATIONSHIP TO DNA SYNTHESIS.小鼠表皮对致癌物敏感性的昼夜变化及其与DNA合成的关系。

J Natl Cancer Inst. 1964 Jun;32:1213-20. doi: 10.1093/jnci/32.6.1213.

[STUDIES ON DIFFERENT EFFECTS OF COCARCINOGENS AND CARCINOGENS ON THE MOUSE EPIDERMIS].

Beitr Pathol Anat. 1964 Feb;129:307-30.

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