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近端胃迷走神经切断术七年随访:临床结果

A seven-year follow-up of proximal gastric vagotomy. Clinical results.

作者信息

Liavåg I, Roland M

出版信息

Scand J Gastroenterol. 1979;14(1):49-56. doi: 10.3109/00365527909179845.

Abstract

During a 7-year period proximal gastric vagotomy (PGV) was performed in 565 patients. Of these, 210 patients with duodenal ulcer and 14 with dyspepsia without demonstrable ulcer at the time of operation were followed for 5--7 years. Sixty-six percent are symptom-free (Visick I), 23% have no complaints when they take certain dietary measures (Visick II), 3% are improved but still have periods of dyspepsia (Visick III), and 8% are failures because of recurrent ulcer (Visick IV). There were 4 duodenal, 3 pyloric, 5 prepyloric, and 7 lesser-curve gastric recurrences. There were one operative death (0.2%) and one major complication (0.2%). The side effects after PGV are mild, infrequent, and seldom of any significance to the patients. Diarrhoea and dumping are virtually eliminated. Body weight was stable during the whole period of study, and blood chemistry did not disclose any deficiency in haemoglobin, serum iron, or vitamin B12 which might be attributed to PGV. It is concluded that 5--7 years after proximal gastric vagotomy for duodenal ulcer there is a 10% recurrence rate, but the low risk of death and of severe complications and the lack of significant side effects more than outweight the high recurrence rate.

摘要

在7年时间里,对565例患者实施了近端胃迷走神经切断术(PGV)。其中,210例十二指肠溃疡患者以及14例手术时无明显溃疡的消化不良患者接受了5至7年的随访。66%的患者无症状(Visick I级),23%的患者在采取特定饮食措施时无不适(Visick II级),3%的患者病情有所改善但仍有消化不良发作期(Visick III级),8%的患者因溃疡复发而治疗失败(Visick IV级)。十二指肠复发4例,幽门复发3例,幽门前复发5例,胃小弯复发7例。有1例手术死亡(0.2%)和1例严重并发症(0.2%)。PGV术后的副作用轻微、不常见,对患者几乎没有任何影响。腹泻和倾倒综合征几乎消除。在整个研究期间体重保持稳定,血液化学检查未发现任何可能归因于PGV的血红蛋白、血清铁或维生素B12缺乏。得出的结论是,十二指肠溃疡近端胃迷走神经切断术后5至7年的复发率为10%,但低死亡风险和严重并发症风险以及缺乏明显副作用远远超过了高复发率。

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