Blank M S, Panerai A E, Friesen H G
Science. 1979 Mar 16;203(4385):1129-31. doi: 10.1126/science.424743.
Subcutaneous injections of naloxone, an opiate antagonist, lead to an increase in serum luteinizing hormone concentrations in female but not in male rats before they reach puberty. In addition, estradiol benzoate specifically blocks the luteinizing hormone response to naloxone in prepubertal female rats, suggesting that the opioid peptides have a physiological role in the endocrine events leading to sexual maturation.
皮下注射阿片类拮抗剂纳洛酮，会使未达青春期的雌性大鼠血清促黄体生成素浓度升高，但对雄性大鼠无此作用。此外，苯甲酸雌二醇可特异性阻断青春期前雌性大鼠对纳洛酮的促黄体生成素反应，这表明阿片肽在导致性成熟的内分泌事件中具有生理作用。
